Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein

Jason J. Chen, Carl E. Reid, Vimla Band, Elliot J. Androphy

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

Human papillomaviruses (HPVs) are associated with the majority of cervical cancers and encode a transforming protein, E6, that interacts with the tumor suppressor protein p53. Because E6 has p53-independent transforming activity, the yeast two-hybrid system was used to search for other E6-binding proteins. One such protein, E6BP, interacted with cancer-associated HPV E6 and with bovine papillomavirus type 1 (BPV-1) E6. The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability. E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.

Original languageEnglish (US)
Pages (from-to)529-531
Number of pages3
JournalScience
Volume269
Issue number5223
DOIs
StatePublished - Jan 1 1995

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Bovine papillomavirus 1
Calcium-Binding Proteins
Oncogene Proteins
Tumor Suppressor Protein p53
Two-Hybrid System Techniques
Uterine Cervical Neoplasms
Endoplasmic Reticulum
Carrier Proteins
Proteins
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. / Chen, Jason J.; Reid, Carl E.; Band, Vimla; Androphy, Elliot J.

In: Science, Vol. 269, No. 5223, 01.01.1995, p. 529-531.

Research output: Contribution to journalArticle

Chen, Jason J. ; Reid, Carl E. ; Band, Vimla ; Androphy, Elliot J. / Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. In: Science. 1995 ; Vol. 269, No. 5223. pp. 529-531.
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