Interaction of Nanosized Copolymer Networks with Oppositely Charged Amphiphilic Molecules

Tatiana K Bronich, Serguei V. Vinogradov, Alexander V. Kabanov

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

A new class of nanocomposite materials is synthesized by reacting nanoscale networks of cross-linked hydrophilic nonionic and cationic polymers, poly(ethylene oxide)-cl-polyethyleneimine, with anionic surfactants. Formation of hydrophobic domains from polyethyleneimine-surfactant complexes leads to a network collapse exhibited in a decrease in the particle size from ca. 300 nm to ca. 50 nm. Due to their cross-linked architecture, the poly(ethylene oxide)-cl-polyethyleneimine-based complexes are more resistant to the changes in the environmental characteristics, such as pH and salt concentration, compared to complexes formed by a graft copolymer, poly(ethylene oxide)-g-polyethyleneimine and surfactants. Poorly soluble biologically active molecules, retinoic acid and indomethacin, were immobilized in the network complexes forming stable aqueous dispersions. The release of the drug from the network dispersion has been demonstrated. These materials are potentially useful as carriers in pharmaceutical drug delivery applications.

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalNano Letters
Volume1
Issue number10
DOIs
StatePublished - Dec 1 2001

Fingerprint

Polyethyleneimine
Polyethylene oxides
copolymers
Copolymers
ethylene oxide
Molecules
surfactants
Surface active agents
Surface-Active Agents
molecules
drugs
Anionic surfactants
Graft copolymers
Complex networks
interactions
Drug delivery
Dispersions
Drug products
Nanocomposites
Tretinoin

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Interaction of Nanosized Copolymer Networks with Oppositely Charged Amphiphilic Molecules. / Bronich, Tatiana K; Vinogradov, Serguei V.; Kabanov, Alexander V.

In: Nano Letters, Vol. 1, No. 10, 01.12.2001, p. 535-540.

Research output: Contribution to journalArticle

Bronich, Tatiana K ; Vinogradov, Serguei V. ; Kabanov, Alexander V. / Interaction of Nanosized Copolymer Networks with Oppositely Charged Amphiphilic Molecules. In: Nano Letters. 2001 ; Vol. 1, No. 10. pp. 535-540.
@article{a1b6f8348ae444e2b9185d8a674d8803,
title = "Interaction of Nanosized Copolymer Networks with Oppositely Charged Amphiphilic Molecules",
abstract = "A new class of nanocomposite materials is synthesized by reacting nanoscale networks of cross-linked hydrophilic nonionic and cationic polymers, poly(ethylene oxide)-cl-polyethyleneimine, with anionic surfactants. Formation of hydrophobic domains from polyethyleneimine-surfactant complexes leads to a network collapse exhibited in a decrease in the particle size from ca. 300 nm to ca. 50 nm. Due to their cross-linked architecture, the poly(ethylene oxide)-cl-polyethyleneimine-based complexes are more resistant to the changes in the environmental characteristics, such as pH and salt concentration, compared to complexes formed by a graft copolymer, poly(ethylene oxide)-g-polyethyleneimine and surfactants. Poorly soluble biologically active molecules, retinoic acid and indomethacin, were immobilized in the network complexes forming stable aqueous dispersions. The release of the drug from the network dispersion has been demonstrated. These materials are potentially useful as carriers in pharmaceutical drug delivery applications.",
author = "Bronich, {Tatiana K} and Vinogradov, {Serguei V.} and Kabanov, {Alexander V.}",
year = "2001",
month = "12",
day = "1",
doi = "10.1021/nl0100365",
language = "English (US)",
volume = "1",
pages = "535--540",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "10",

}

TY - JOUR

T1 - Interaction of Nanosized Copolymer Networks with Oppositely Charged Amphiphilic Molecules

AU - Bronich, Tatiana K

AU - Vinogradov, Serguei V.

AU - Kabanov, Alexander V.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - A new class of nanocomposite materials is synthesized by reacting nanoscale networks of cross-linked hydrophilic nonionic and cationic polymers, poly(ethylene oxide)-cl-polyethyleneimine, with anionic surfactants. Formation of hydrophobic domains from polyethyleneimine-surfactant complexes leads to a network collapse exhibited in a decrease in the particle size from ca. 300 nm to ca. 50 nm. Due to their cross-linked architecture, the poly(ethylene oxide)-cl-polyethyleneimine-based complexes are more resistant to the changes in the environmental characteristics, such as pH and salt concentration, compared to complexes formed by a graft copolymer, poly(ethylene oxide)-g-polyethyleneimine and surfactants. Poorly soluble biologically active molecules, retinoic acid and indomethacin, were immobilized in the network complexes forming stable aqueous dispersions. The release of the drug from the network dispersion has been demonstrated. These materials are potentially useful as carriers in pharmaceutical drug delivery applications.

AB - A new class of nanocomposite materials is synthesized by reacting nanoscale networks of cross-linked hydrophilic nonionic and cationic polymers, poly(ethylene oxide)-cl-polyethyleneimine, with anionic surfactants. Formation of hydrophobic domains from polyethyleneimine-surfactant complexes leads to a network collapse exhibited in a decrease in the particle size from ca. 300 nm to ca. 50 nm. Due to their cross-linked architecture, the poly(ethylene oxide)-cl-polyethyleneimine-based complexes are more resistant to the changes in the environmental characteristics, such as pH and salt concentration, compared to complexes formed by a graft copolymer, poly(ethylene oxide)-g-polyethyleneimine and surfactants. Poorly soluble biologically active molecules, retinoic acid and indomethacin, were immobilized in the network complexes forming stable aqueous dispersions. The release of the drug from the network dispersion has been demonstrated. These materials are potentially useful as carriers in pharmaceutical drug delivery applications.

UR - http://www.scopus.com/inward/record.url?scp=0000459335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000459335&partnerID=8YFLogxK

U2 - 10.1021/nl0100365

DO - 10.1021/nl0100365

M3 - Article

VL - 1

SP - 535

EP - 540

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 10

ER -