Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

Nora Sarvetnick, Denny Liggitt, Sharon L. Pitts, Stanley E. Hansen, Timothy A. Stewart

Research output: Contribution to journalArticle

393 Citations (Scopus)

Abstract

We have produced transgenic mouse strains harboring class II major histocompatibility complex or interferon-gamma genes linked to the human insulin promoter. These experiments were designed to investigate the consequences of the expression of immunological effector molecules by nonimmunological cells. In both of these studies we observed the disappearance from the pancreas of the insulin-producing β cells coinciding with the development of insulin-dependent diabetes mellitus. Transgenic mice expressing both chains of the I-A gene showed progressive atrophy of the islets of Langerhans, whereas mice expressing interferon-gamma suffered an inflammatory destruction of the islets.

Original languageEnglish (US)
Pages (from-to)773-782
Number of pages10
JournalCell
Volume52
Issue number5
DOIs
StatePublished - Mar 11 1988

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Medical problems
Type 1 Diabetes Mellitus
Transgenic Mice
Interferon-gamma
Insulin
Genes
Major Histocompatibility Complex
Islets of Langerhans
Atrophy
Pancreas
Molecules
Ectopic Gene Expression
Experiments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. / Sarvetnick, Nora; Liggitt, Denny; Pitts, Sharon L.; Hansen, Stanley E.; Stewart, Timothy A.

In: Cell, Vol. 52, No. 5, 11.03.1988, p. 773-782.

Research output: Contribution to journalArticle

Sarvetnick, Nora ; Liggitt, Denny ; Pitts, Sharon L. ; Hansen, Stanley E. ; Stewart, Timothy A. / Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. In: Cell. 1988 ; Vol. 52, No. 5. pp. 773-782.
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