Inorganic arsenic

a nongenotoxic threshold carcinogen

Samuel Monroe Cohen, Lora L. Arnold, Joyce S. Tsuji

Research output: Contribution to journalReview article

Abstract

Inorganic arsenic (iA) in the drinking water is a human carcinogen (bladder, lung, and skin). The mode of action involves metabolism to trivalent arsenicals that react with sulfhydryl groups in critical proteins, leading to cytotoxicity with regenerative proliferation, involving a threshold at in vitro concentrations >0.1 μM. Adverse biologic effects at such tissue concentrations in rodents occur with ≥10 ppm of iAs in diet or drinking water. On the basis of mode of action, in vitro, and in vivo studies, anticipated drinking water exposures of 50–150 μg/L exceed a tissue concentration of >0.1 μM in humans. Epidemiologic investigations evaluating populations exposed at levels <150 μg/L iAs in drinking water are consistent with such a threshold for cancer.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalCurrent Opinion in Toxicology
Volume14
DOIs
StatePublished - Apr 1 2019

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Arsenic
Drinking Water
Carcinogens
Tissue
Arsenicals
Cytotoxicity
Nutrition
Metabolism
Rodentia
Skin
Urinary Bladder
Diet
Lung
Population
Neoplasms
Proteins
In Vitro Techniques

Keywords

  • Inorganic arsenic
  • Risk assessment
  • bladder cancer
  • lung cancer
  • skin cancer
  • threshold

ASJC Scopus subject areas

  • Toxicology

Cite this

Inorganic arsenic : a nongenotoxic threshold carcinogen. / Cohen, Samuel Monroe; Arnold, Lora L.; Tsuji, Joyce S.

In: Current Opinion in Toxicology, Vol. 14, 01.04.2019, p. 8-13.

Research output: Contribution to journalReview article

Cohen, Samuel Monroe ; Arnold, Lora L. ; Tsuji, Joyce S. / Inorganic arsenic : a nongenotoxic threshold carcinogen. In: Current Opinion in Toxicology. 2019 ; Vol. 14. pp. 8-13.
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