Innate and adaptive immunity in health and disease

Howard Eliot Gendelman, Eliezer Masliah

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Neuroinflammatory processes play a significant role in health and disease of the nervous system. These regulate development, maintenance, and sustenance of brain cells and their connections. Linked to aging, epidemiologic, animal, human, and therapeutic studies all support the presence of a neuroinflammatory cascade in disease. This is highlighted by the neurotoxic potential of microglia. In steady state, microglia serve to protect the nervous system by acting as debris scavengers, killers of microbial pathogens, and regulators of innate and adaptive immune responses. In neurodegenerative diseases, activated microglia affect neuronal injury and death through production of glutamate, proinflammatory factors, reactive oxygen species, quinolinic acid amongst others and by mobilization of adaptive immune responses and cell chemotaxis leading to transendothelial migration of immunocytes across the blood-brain barrier and perpetuation of neural damage. As disease progresses, inflammatory secretions engage neighboring glial cells, including astrocytes and endothelial cells, resulting in a vicious cycle of autocrine and paracrine amplification of inflammation perpetuating tissue injury. Such pathogenic processes contribute to neurodegeneration. Research from others and our own laboratories seek to harness such inflammatory processes with the singular goal of developing therapeutic interventions that positively affect the tempo and progression of human disease (Crutcher et al., 2006).

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer US
Pages7-8
Number of pages2
ISBN (Print)9780387725727
DOIs
StatePublished - Dec 1 2008

Fingerprint

Microglia
Adaptive Immunity
Innate Immunity
Health
Quinolinic Acid
Transendothelial and Transepithelial Migration
Wounds and Injuries
Chemotaxis
Nervous System Diseases
Blood-Brain Barrier
Neuroglia
Astrocytes
Neurodegenerative Diseases
Nervous System
Disease Progression
Glutamic Acid
Reactive Oxygen Species
Endothelial Cells
Maintenance
Inflammation

Keywords

  • Innate and adaptive immunity
  • Neurodegenation, Synapse loss
  • Neuroinfl ammation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Gendelman, H. E., & Masliah, E. (2008). Innate and adaptive immunity in health and disease. In Neuroimmune Pharmacology (pp. 7-8). Springer US. https://doi.org/10.1007/978-0-387-72573-4_2

Innate and adaptive immunity in health and disease. / Gendelman, Howard Eliot; Masliah, Eliezer.

Neuroimmune Pharmacology. Springer US, 2008. p. 7-8.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gendelman, HE & Masliah, E 2008, Innate and adaptive immunity in health and disease. in Neuroimmune Pharmacology. Springer US, pp. 7-8. https://doi.org/10.1007/978-0-387-72573-4_2
Gendelman HE, Masliah E. Innate and adaptive immunity in health and disease. In Neuroimmune Pharmacology. Springer US. 2008. p. 7-8 https://doi.org/10.1007/978-0-387-72573-4_2
Gendelman, Howard Eliot ; Masliah, Eliezer. / Innate and adaptive immunity in health and disease. Neuroimmune Pharmacology. Springer US, 2008. pp. 7-8
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