Inhibitory mediation of catecholamines for anticonvulsant activity of sodium valproate

S. S. Parmar, A. K. Chaturvedi, J. D. Geiger, S. J. Brumleve

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Abstract

The chance discovery of antiepileptic activity of valproic acid (n-dipropyl-acetic acid) by Meunier et al. has led to its use in the treatment of epileptic patients. Sodium valproate has been shown to provide protection against pentylenetetrazol induced seizures in mice and GABA acid has been proposed to play a role in the expression of the anticonvulsant activity of valproic acid. The role of central catecholamines as mediators of the anticonvulsant activity has been reported earlier for diazepam, flurazepam and chlordiazepoxide. These observations have prompted the present investigations to elucidate the role of catecholamines in the anticonvulsant activity of sodium valproate.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalProceedings of the Western Pharmacology Society
VolumeVol. 25
Publication statusPublished - Jan 1 1982

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ASJC Scopus subject areas

  • Pharmacology

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