Inhibition of platelet aggregation by novel triphenylethylene analogs

Gundu H.R. Rao, Vargese John, Timothy D. Hill, J. L. Vennerstrom, James G. White, T. J. Holmes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present study has evaluated the effect of some newly synthesized triphenylethylene (TPE) analogs on platelet arachidonic acid metabolism and function. All compounds tested inhibited arachidonic acid induced platelet aggregation and several were superior to aspirin in their relative potency. Introduction of a carboxyl function into the alpha-ring, which should enhance binding according to proposed structural models for cyclooxygenase inhibitors, was not found to be beneficial. Increased structural rigidity, which resulted from covalent linkage of two aromatic rings in this series, did not eliminate anti-aggregatory properties.

Original languageEnglish (US)
Pages (from-to)527-538
Number of pages12
JournalThrombosis Research
Volume44
Issue number4
DOIs
StatePublished - Nov 15 1986

Fingerprint

Platelet Aggregation
Arachidonic Acid
Cyclooxygenase Inhibitors
Structural Models
Aspirin
Blood Platelets
triphenylethylene

Keywords

  • anti-platelet drugs
  • platelet aggregation
  • platelet cyclooxygenases
  • triphenylethylene analogs

ASJC Scopus subject areas

  • Hematology

Cite this

Inhibition of platelet aggregation by novel triphenylethylene analogs. / Rao, Gundu H.R.; John, Vargese; Hill, Timothy D.; Vennerstrom, J. L.; White, James G.; Holmes, T. J.

In: Thrombosis Research, Vol. 44, No. 4, 15.11.1986, p. 527-538.

Research output: Contribution to journalArticle

Rao, Gundu H.R. ; John, Vargese ; Hill, Timothy D. ; Vennerstrom, J. L. ; White, James G. ; Holmes, T. J. / Inhibition of platelet aggregation by novel triphenylethylene analogs. In: Thrombosis Research. 1986 ; Vol. 44, No. 4. pp. 527-538.
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