Inhibition of platelet aggregation by novel triphenylethylene analogs

Gundu H.R. Rao, Vargese John, Timothy D. Hill, J. L. Vennerstrom, James G. White, T. J. Holmes

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The present study has evaluated the effect of some newly synthesized triphenylethylene (TPE) analogs on platelet arachidonic acid metabolism and function. All compounds tested inhibited arachidonic acid induced platelet aggregation and several were superior to aspirin in their relative potency. Introduction of a carboxyl function into the alpha-ring, which should enhance binding according to proposed structural models for cyclooxygenase inhibitors, was not found to be beneficial. Increased structural rigidity, which resulted from covalent linkage of two aromatic rings in this series, did not eliminate anti-aggregatory properties.

Original languageEnglish (US)
Pages (from-to)527-538
Number of pages12
JournalThrombosis Research
Volume44
Issue number4
DOIs
StatePublished - Nov 15 1986

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Keywords

  • anti-platelet drugs
  • platelet aggregation
  • platelet cyclooxygenases
  • triphenylethylene analogs

ASJC Scopus subject areas

  • Hematology

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