Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate

L. Guo, N. K. Heinzinger, M. Stevenson, Lawrence M Schopfer, J. M. Salhany

Research output: Contribution to journalComment/debate

9 Citations (Scopus)

Abstract

Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine- reactive and anionic substituents.

Original languageEnglish (US)
Pages (from-to)2483-2487
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume38
Issue number10
DOIs
StatePublished - Jan 1 1994

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Pyridoxal Phosphate
Virus Diseases
HIV-1
Lysine
Antiviral Agents
HIV
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate. / Guo, L.; Heinzinger, N. K.; Stevenson, M.; Schopfer, Lawrence M; Salhany, J. M.

In: Antimicrobial Agents and Chemotherapy, Vol. 38, No. 10, 01.01.1994, p. 2483-2487.

Research output: Contribution to journalComment/debate

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