Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia

D. Lekieffre, O. Ghribi, J. Callebert, M. Allix, M. Plotkine, R. G. Boulu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/kg) on ischemia-induced hippocampal glutamate release and neuronal damage. Kynurenic acid significantly decreased glutamate release during ischemia but had no effect on the hippocampal lesion. Some protection was observed in the cortex and in the striatum. These data suggested that the extracellular accumulation of glutamate during forebrain ischemia does not play a major role in the hippocampus.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalBrain Research
Volume592
Issue number1-2
DOIs
StatePublished - Oct 2 1992

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Kynurenic Acid
Prosencephalon
Glutamic Acid
Hippocampus
Ischemia

Keywords

  • Forebrain ischemia
  • Glutamate
  • Hippocampus
  • Kynurenic acid
  • Microdialysis
  • Neuronal death
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia. / Lekieffre, D.; Ghribi, O.; Callebert, J.; Allix, M.; Plotkine, M.; Boulu, R. G.

In: Brain Research, Vol. 592, No. 1-2, 02.10.1992, p. 333-337.

Research output: Contribution to journalArticle

Lekieffre, D. ; Ghribi, O. ; Callebert, J. ; Allix, M. ; Plotkine, M. ; Boulu, R. G. / Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia. In: Brain Research. 1992 ; Vol. 592, No. 1-2. pp. 333-337.
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