Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia

D. Lekieffre, O. Ghribi, J. Callebert, M. Allix, M. Plotkine, R. G. Boulu

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/kg) on ischemia-induced hippocampal glutamate release and neuronal damage. Kynurenic acid significantly decreased glutamate release during ischemia but had no effect on the hippocampal lesion. Some protection was observed in the cortex and in the striatum. These data suggested that the extracellular accumulation of glutamate during forebrain ischemia does not play a major role in the hippocampus.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalBrain Research
Volume592
Issue number1-2
DOIs
StatePublished - Oct 2 1992

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Keywords

  • Forebrain ischemia
  • Glutamate
  • Hippocampus
  • Kynurenic acid
  • Microdialysis
  • Neuronal death
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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