Inhibition of Fusarium graminearum growth and development by farnesol

Camile P. Semighini, Nicholas Murray, Steven D. Harris

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The isoprenoid farnesol was previously shown to induce morphological features characteristic of apoptosis in the filamentous fungus Aspergillus nidulans. This study demonstrates that under similar liquid media growth conditions, farnesol also triggers apoptosis in the plant pathogenic fungus Fusarium graminearum. However, unlike A. nidulans, F. graminearum spores treated with farnesol exhibited altered germination patterns and most (>60%) lysed upon prolonged exposure. Given the economic importance of F. graminearum as a pathogen of small grains, this study proposes that farnesol may have potential value as an antifungal compound.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalFEMS Microbiology Letters
Volume279
Issue number2
DOIs
StatePublished - Feb 1 2008

Fingerprint

Farnesol
Fusarium
Growth and Development
Aspergillus nidulans
Fungi
Apoptosis
Terpenes
Germination
Spores
Economics
Growth

Keywords

  • Antifungal
  • Apoptosis
  • Farnesol
  • Fusarium graminearum
  • Macroconidia
  • Spore germination

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

Cite this

Inhibition of Fusarium graminearum growth and development by farnesol. / Semighini, Camile P.; Murray, Nicholas; Harris, Steven D.

In: FEMS Microbiology Letters, Vol. 279, No. 2, 01.02.2008, p. 259-264.

Research output: Contribution to journalArticle

Semighini, Camile P. ; Murray, Nicholas ; Harris, Steven D. / Inhibition of Fusarium graminearum growth and development by farnesol. In: FEMS Microbiology Letters. 2008 ; Vol. 279, No. 2. pp. 259-264.
@article{2030efd343834d409f92fbb3acbec524,
title = "Inhibition of Fusarium graminearum growth and development by farnesol",
abstract = "The isoprenoid farnesol was previously shown to induce morphological features characteristic of apoptosis in the filamentous fungus Aspergillus nidulans. This study demonstrates that under similar liquid media growth conditions, farnesol also triggers apoptosis in the plant pathogenic fungus Fusarium graminearum. However, unlike A. nidulans, F. graminearum spores treated with farnesol exhibited altered germination patterns and most (>60{\%}) lysed upon prolonged exposure. Given the economic importance of F. graminearum as a pathogen of small grains, this study proposes that farnesol may have potential value as an antifungal compound.",
keywords = "Antifungal, Apoptosis, Farnesol, Fusarium graminearum, Macroconidia, Spore germination",
author = "Semighini, {Camile P.} and Nicholas Murray and Harris, {Steven D.}",
year = "2008",
month = "2",
day = "1",
doi = "10.1111/j.1574-6968.2007.01042.x",
language = "English (US)",
volume = "279",
pages = "259--264",
journal = "FEMS Microbiology Letters",
issn = "0378-1097",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Inhibition of Fusarium graminearum growth and development by farnesol

AU - Semighini, Camile P.

AU - Murray, Nicholas

AU - Harris, Steven D.

PY - 2008/2/1

Y1 - 2008/2/1

N2 - The isoprenoid farnesol was previously shown to induce morphological features characteristic of apoptosis in the filamentous fungus Aspergillus nidulans. This study demonstrates that under similar liquid media growth conditions, farnesol also triggers apoptosis in the plant pathogenic fungus Fusarium graminearum. However, unlike A. nidulans, F. graminearum spores treated with farnesol exhibited altered germination patterns and most (>60%) lysed upon prolonged exposure. Given the economic importance of F. graminearum as a pathogen of small grains, this study proposes that farnesol may have potential value as an antifungal compound.

AB - The isoprenoid farnesol was previously shown to induce morphological features characteristic of apoptosis in the filamentous fungus Aspergillus nidulans. This study demonstrates that under similar liquid media growth conditions, farnesol also triggers apoptosis in the plant pathogenic fungus Fusarium graminearum. However, unlike A. nidulans, F. graminearum spores treated with farnesol exhibited altered germination patterns and most (>60%) lysed upon prolonged exposure. Given the economic importance of F. graminearum as a pathogen of small grains, this study proposes that farnesol may have potential value as an antifungal compound.

KW - Antifungal

KW - Apoptosis

KW - Farnesol

KW - Fusarium graminearum

KW - Macroconidia

KW - Spore germination

UR - http://www.scopus.com/inward/record.url?scp=38349160235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349160235&partnerID=8YFLogxK

U2 - 10.1111/j.1574-6968.2007.01042.x

DO - 10.1111/j.1574-6968.2007.01042.x

M3 - Article

C2 - 18201191

AN - SCOPUS:38349160235

VL - 279

SP - 259

EP - 264

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

SN - 0378-1097

IS - 2

ER -