Influence of vagotomy on the baroreflex sensitivity in anesthetized dogs with experimental heart failure

W. Wang, M. Brandle, Irving H Zucker

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In a previous study (Wang, W., J. S. Chen, and I. H. Zucker, Circ. Res. 68:1294-1301, 1991), we showed a depression in baroreflex gain in dogs with pacing-induced heart failure. This depression was not accompanied by a decrease in the central gain (carotid sinus nerve stimulation vs. renal nerve activity). These previous experiments were carried out on animals that were vagotomized and aortic denervated. In the present study these experiments were repeated, and the data were analyzed both in the intact and vagotomized state. Dogs were cardiac paced at 250 beats/min until heart failure was noted. Sham dogs were used as controls. The carotid sinuses were isolated, and the aortic nerves were sectioned. Activity from a renal sympathetic nerve (RSNA) was recorded with arterial pressure and carotid sinus pressure (CSP) during bilateral step increases in CSP from 25 to 300 mmHg. Mean arterial pressure (MAP) and RSNA responses to carotid sinus pressurization and to carotid sinus nerve stimulation were tested before and after bilateral vagotomy, and curves describing these relationships were constructed. Before vagotomy, the peak response relating stimulation frequency to MAP was significantly depressed in dogs with heart failure (-18.3 ± 4.7 vs. -37.0 ± 2.2%, P < 0.001). In addition, the CSP-MAP curves were depressed in dogs with heart failure. Frequency-RSNA curves were not altered in heart failure. There were no significant changes in the baroreflex gain responses to pressurization or electrical stimulation after vagotomy in either sham or heart failure groups. These data suggest there is no influence of vagal afferents in the baroreflex inhibition in anesthetized dogs with or without heart failure.

Original languageEnglish (US)
Pages (from-to)H1310-H1317
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume265
Issue number4 34-4
StatePublished - Jan 1 1993

Fingerprint

Carotid Sinus
Baroreflex
Vagotomy
heart failure
sinuses
Heart Failure
Dogs
nerve tissue
dogs
Arterial Pressure
Pressure
kidneys
Kidney
Electric Stimulation

Keywords

  • blood pressure
  • renal nerve activity

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Influence of vagotomy on the baroreflex sensitivity in anesthetized dogs with experimental heart failure. / Wang, W.; Brandle, M.; Zucker, Irving H.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 265, No. 4 34-4, 01.01.1993, p. H1310-H1317.

Research output: Contribution to journalArticle

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