Influence of the etiology of pancreatitis on the natural history of pancreatic pseudocysts

Bao Lien T Nguyen, Jon S Thompson, James A. Edney, Larry E. Bragg, Layton F. Rikkers

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Abstract

We reviewed our experience with 90 patients with pancreatic pseudocysts to determine if the cause of pancreatitis influenced the patients' outcome. Acute pancreatitis (AP) occurred in 57 (63%) patients due to alcoholic (n = 15), postoperative (n = 14), biliary (n = 12), and other etiologies (n = 16). Thirty-three (37%) patients had chronic pancreatitis (CP) secondary to alcohol use (n = 27) or other causes (n = 6). Multiple pseudocysts were significantly more frequent in patients with acute alcoholic pancreatitis than in patients with chronic pancreatitis (47% versus 19%, p < 0.05). Spontaneous resolution occurred within 8 weeks in 10 (11%) patients with pseudocysts (AP = 9%, CP = 15%, p = NS). However, no patient with pseudocyst associated with biliary or postoperative pancreatitis underwent spontaneous resolution. Although pseudocysts associated with chronic pancreatitis were smaller in size (8.0 ± 4.7 versus 5.7 ± 3.8 cm, p < 0.05), a similar proportion of them required operation compared with AP pseudocysts (56% versus 58%). There were significantly more deaths in patients with postoperative pancreatitis compared with all other groups (29% versus 7%, p < 0.05). The outcome of pseudocysts was similar regardless of size (greater than 6 cm versus less than 6 cm) and presentation (acute versus delayed). Thus, the etiology of pancreatitis was a more important determinant of pseudocyst outcome than pseudocyst size or presentation.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalThe American Journal of Surgery
Volume162
Issue number6
DOIs
StatePublished - Dec 1991

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Pancreatic Pseudocyst
Pancreatitis
Chronic Pancreatitis
Alcoholic Pancreatitis
Alcohols

ASJC Scopus subject areas

  • Surgery

Cite this

Influence of the etiology of pancreatitis on the natural history of pancreatic pseudocysts. / Nguyen, Bao Lien T; Thompson, Jon S; Edney, James A.; Bragg, Larry E.; Rikkers, Layton F.

In: The American Journal of Surgery, Vol. 162, No. 6, 12.1991, p. 527-531.

Research output: Contribution to journalArticle

Nguyen, Bao Lien T ; Thompson, Jon S ; Edney, James A. ; Bragg, Larry E. ; Rikkers, Layton F. / Influence of the etiology of pancreatitis on the natural history of pancreatic pseudocysts. In: The American Journal of Surgery. 1991 ; Vol. 162, No. 6. pp. 527-531.
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