Influence of protein tyrosine kinases on cell volume change-induced taurine release

Herminia Pasantes-Morales, Rodrigo Franco-Cruz

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Taurine efflux occurs in association with cell swelling in both hyposmotic and isosmotic conditions and during cell shrinkage in apoptotic death. Release occurs through a leak pathway, is largely Ca2+-independent and is sensitive to Cl- channel blockers. Taurine efflux elicited by hyposmolarity is reduced or suppressed by tyrosine kinase blockers and increased by tyrosine phosphatase inhibitors. The specific kinases involved are still unknown and may be different in the various cell types. Non-receptor and scr-related protein kinases have been identified in some cells as elements that directly phosphorylate the taurine efflux pathway. Possible tyrosine kinase targets are the phosphinositide kinase (PI3K), which if inhibited, prevents the osmosensitive taurine efflux in brain cells, or the small GTP-binding proteins associated with remodeling of the cytoskeleton. The similar effects of tyrosine kinase modulators on volume-activated taurine fluxes and Cl- currents are suggestive of either a shared translocation pathway or a common step in the signaling network. The effects of tyrosine kinases on taurine efflux activated in isosmotic swelling and in the release associated with apoptosis are essentially unexplored.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalCerebellum
Volume1
Issue number2
DOIs
StatePublished - Apr 1 2002

Fingerprint

Taurine
Cell Size
Protein-Tyrosine Kinases
Phosphotransferases
Cytoskeleton
Phosphatidylinositol 3-Kinases
GTP-Binding Proteins
Phosphoric Monoester Hydrolases
Protein Kinases
Tyrosine
Apoptosis
Brain

Keywords

  • Hyposmolarity
  • Osmolytes
  • PI3 kinase
  • Swelling

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Influence of protein tyrosine kinases on cell volume change-induced taurine release. / Pasantes-Morales, Herminia; Franco-Cruz, Rodrigo.

In: Cerebellum, Vol. 1, No. 2, 01.04.2002, p. 103-109.

Research output: Contribution to journalReview article

@article{1461c180d921411a824432424cf15a2d,
title = "Influence of protein tyrosine kinases on cell volume change-induced taurine release",
abstract = "Taurine efflux occurs in association with cell swelling in both hyposmotic and isosmotic conditions and during cell shrinkage in apoptotic death. Release occurs through a leak pathway, is largely Ca2+-independent and is sensitive to Cl- channel blockers. Taurine efflux elicited by hyposmolarity is reduced or suppressed by tyrosine kinase blockers and increased by tyrosine phosphatase inhibitors. The specific kinases involved are still unknown and may be different in the various cell types. Non-receptor and scr-related protein kinases have been identified in some cells as elements that directly phosphorylate the taurine efflux pathway. Possible tyrosine kinase targets are the phosphinositide kinase (PI3K), which if inhibited, prevents the osmosensitive taurine efflux in brain cells, or the small GTP-binding proteins associated with remodeling of the cytoskeleton. The similar effects of tyrosine kinase modulators on volume-activated taurine fluxes and Cl- currents are suggestive of either a shared translocation pathway or a common step in the signaling network. The effects of tyrosine kinases on taurine efflux activated in isosmotic swelling and in the release associated with apoptosis are essentially unexplored.",
keywords = "Hyposmolarity, Osmolytes, PI3 kinase, Swelling",
author = "Herminia Pasantes-Morales and Rodrigo Franco-Cruz",
year = "2002",
month = "4",
day = "1",
doi = "10.1080/147342202753671231",
language = "English (US)",
volume = "1",
pages = "103--109",
journal = "Cerebellum",
issn = "1473-4222",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Influence of protein tyrosine kinases on cell volume change-induced taurine release

AU - Pasantes-Morales, Herminia

AU - Franco-Cruz, Rodrigo

PY - 2002/4/1

Y1 - 2002/4/1

N2 - Taurine efflux occurs in association with cell swelling in both hyposmotic and isosmotic conditions and during cell shrinkage in apoptotic death. Release occurs through a leak pathway, is largely Ca2+-independent and is sensitive to Cl- channel blockers. Taurine efflux elicited by hyposmolarity is reduced or suppressed by tyrosine kinase blockers and increased by tyrosine phosphatase inhibitors. The specific kinases involved are still unknown and may be different in the various cell types. Non-receptor and scr-related protein kinases have been identified in some cells as elements that directly phosphorylate the taurine efflux pathway. Possible tyrosine kinase targets are the phosphinositide kinase (PI3K), which if inhibited, prevents the osmosensitive taurine efflux in brain cells, or the small GTP-binding proteins associated with remodeling of the cytoskeleton. The similar effects of tyrosine kinase modulators on volume-activated taurine fluxes and Cl- currents are suggestive of either a shared translocation pathway or a common step in the signaling network. The effects of tyrosine kinases on taurine efflux activated in isosmotic swelling and in the release associated with apoptosis are essentially unexplored.

AB - Taurine efflux occurs in association with cell swelling in both hyposmotic and isosmotic conditions and during cell shrinkage in apoptotic death. Release occurs through a leak pathway, is largely Ca2+-independent and is sensitive to Cl- channel blockers. Taurine efflux elicited by hyposmolarity is reduced or suppressed by tyrosine kinase blockers and increased by tyrosine phosphatase inhibitors. The specific kinases involved are still unknown and may be different in the various cell types. Non-receptor and scr-related protein kinases have been identified in some cells as elements that directly phosphorylate the taurine efflux pathway. Possible tyrosine kinase targets are the phosphinositide kinase (PI3K), which if inhibited, prevents the osmosensitive taurine efflux in brain cells, or the small GTP-binding proteins associated with remodeling of the cytoskeleton. The similar effects of tyrosine kinase modulators on volume-activated taurine fluxes and Cl- currents are suggestive of either a shared translocation pathway or a common step in the signaling network. The effects of tyrosine kinases on taurine efflux activated in isosmotic swelling and in the release associated with apoptosis are essentially unexplored.

KW - Hyposmolarity

KW - Osmolytes

KW - PI3 kinase

KW - Swelling

UR - http://www.scopus.com/inward/record.url?scp=0041466111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041466111&partnerID=8YFLogxK

U2 - 10.1080/147342202753671231

DO - 10.1080/147342202753671231

M3 - Review article

VL - 1

SP - 103

EP - 109

JO - Cerebellum

JF - Cerebellum

SN - 1473-4222

IS - 2

ER -