Influence of nutrient delivery on gut structure and function.

L. E. Bragg, Jon S Thompson, L. F. Rikkers

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Food is an important stimulus for the growth of gastrointestinal mucosa. Gut structure is influenced by the route of nutrient administration, dietary composition and the availability of specific nutrients. The alterations in intestinal structure and function that occur when enteral nutrition is withheld suggests that the ingestion of food results in physiologic responses that are responsible for the maintenance of gut mass during the fed state. The mechanism of mucosal suppression that occurs during starvation, stress, and total parenteral nutrition is not completely understood but may involve the absence of luminal substrates, decreased pancreaticobiliary secretions and alterations in the endocrine or paracrine events that normally accompany eating, digestion, and absorption. Enterocytes prefer glutamine and ketone bodies as oxidative fuels, whereas colonocytes utilize short chain fatty acids. Although enteral delivery of nutrients is the preferred route for maintenance of intestinal mass, provision of specific nutrients and hormonal stimulation during parenteral alimentation has been shown to be important in maintaining mucosal structure and function. If not adequately maintained, the intestine becomes susceptible to a variety of injuries which may result in impaired ability to digest and absorb nutrients and loss of mucosal barrier function.

Original languageEnglish (US)
Pages (from-to)237-243
Number of pages7
JournalNutrition (Burbank, Los Angeles County, Calif.)
Volume7
Issue number4
StatePublished - Jul 1 1991

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Food
Eating
Maintenance
Ketone Bodies
Volatile Fatty Acids
Total Parenteral Nutrition
Enterocytes
Enteral Nutrition
Starvation
Glutamine
Small Intestine
Intestines
Digestion
Mucous Membrane
Wounds and Injuries
Growth

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Influence of nutrient delivery on gut structure and function. / Bragg, L. E.; Thompson, Jon S; Rikkers, L. F.

In: Nutrition (Burbank, Los Angeles County, Calif.), Vol. 7, No. 4, 01.07.1991, p. 237-243.

Research output: Contribution to journalReview article

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