Influence of ethanol on in-vivo levels of hepatic methylators betaine and N5 methyltetrahydrofolate in the rat

A. J. Barak, H. Baker, D. J. Tuma

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rats were fed an alcohol-containing diet for periods of 30 days and 60 days. The feeding of this diet produced an accumulation of N5-methyltetrahydrofolate and a decrease in the pool size of betaine in livers at both time periods. Hepatic choline was elevated as a result of the ethanol but phosphorylcholine and the activities of choline kinase and choline oxidase did not change. These findings suggest that betaine may substitute for N5-methyltetrahydrofolate as a methylator of homocysteine in methionine synthesis when methylation by N5-methyltetrahydrofolate is impaired by ethanol.

Original languageEnglish (US)
Pages (from-to)527-528
Number of pages2
JournalIRCS Medical Science
Volume9
Issue number6
StatePublished - Jan 1 1981

Fingerprint

Betaine
choline oxidase
Nutrition
Rats
Ethanol
Choline Kinase
Diet
Methylation
Phosphorylcholine
Liver
Homocysteine
Choline
Methionine
Alcohols

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Influence of ethanol on in-vivo levels of hepatic methylators betaine and N5 methyltetrahydrofolate in the rat. / Barak, A. J.; Baker, H.; Tuma, D. J.

In: IRCS Medical Science, Vol. 9, No. 6, 01.01.1981, p. 527-528.

Research output: Contribution to journalArticle

@article{cfa7a22bb6a649d997c1d2252da398dc,
title = "Influence of ethanol on in-vivo levels of hepatic methylators betaine and N5 methyltetrahydrofolate in the rat",
abstract = "Rats were fed an alcohol-containing diet for periods of 30 days and 60 days. The feeding of this diet produced an accumulation of N5-methyltetrahydrofolate and a decrease in the pool size of betaine in livers at both time periods. Hepatic choline was elevated as a result of the ethanol but phosphorylcholine and the activities of choline kinase and choline oxidase did not change. These findings suggest that betaine may substitute for N5-methyltetrahydrofolate as a methylator of homocysteine in methionine synthesis when methylation by N5-methyltetrahydrofolate is impaired by ethanol.",
author = "Barak, {A. J.} and H. Baker and Tuma, {D. J.}",
year = "1981",
month = "1",
day = "1",
language = "English (US)",
volume = "9",
pages = "527--528",
journal = "IRCS Medical Science",
issn = "0305-6651",
publisher = "MTP International Research Communications ltd.",
number = "6",

}

TY - JOUR

T1 - Influence of ethanol on in-vivo levels of hepatic methylators betaine and N5 methyltetrahydrofolate in the rat

AU - Barak, A. J.

AU - Baker, H.

AU - Tuma, D. J.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Rats were fed an alcohol-containing diet for periods of 30 days and 60 days. The feeding of this diet produced an accumulation of N5-methyltetrahydrofolate and a decrease in the pool size of betaine in livers at both time periods. Hepatic choline was elevated as a result of the ethanol but phosphorylcholine and the activities of choline kinase and choline oxidase did not change. These findings suggest that betaine may substitute for N5-methyltetrahydrofolate as a methylator of homocysteine in methionine synthesis when methylation by N5-methyltetrahydrofolate is impaired by ethanol.

AB - Rats were fed an alcohol-containing diet for periods of 30 days and 60 days. The feeding of this diet produced an accumulation of N5-methyltetrahydrofolate and a decrease in the pool size of betaine in livers at both time periods. Hepatic choline was elevated as a result of the ethanol but phosphorylcholine and the activities of choline kinase and choline oxidase did not change. These findings suggest that betaine may substitute for N5-methyltetrahydrofolate as a methylator of homocysteine in methionine synthesis when methylation by N5-methyltetrahydrofolate is impaired by ethanol.

UR - http://www.scopus.com/inward/record.url?scp=0019427945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019427945&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0019427945

VL - 9

SP - 527

EP - 528

JO - IRCS Medical Science

JF - IRCS Medical Science

SN - 0305-6651

IS - 6

ER -