Influence of ethanol on in-vivo levels of hepatic methylators betaine and N5 methyltetrahydrofolate in the rat

A. J. Barak, H. Baker, D. J. Tuma

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Abstract

Rats were fed an alcohol-containing diet for periods of 30 days and 60 days. The feeding of this diet produced an accumulation of N5-methyltetrahydrofolate and a decrease in the pool size of betaine in livers at both time periods. Hepatic choline was elevated as a result of the ethanol but phosphorylcholine and the activities of choline kinase and choline oxidase did not change. These findings suggest that betaine may substitute for N5-methyltetrahydrofolate as a methylator of homocysteine in methionine synthesis when methylation by N5-methyltetrahydrofolate is impaired by ethanol.

Original languageEnglish (US)
Pages (from-to)527-528
Number of pages2
JournalIRCS Medical Science
Volume9
Issue number6
Publication statusPublished - Jan 1 1981

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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