Influence of alcohol feeding and a choline deficiency on some enzymes of ammonia detoxification in the rat liver

A. J. Barak, K. J. Hahn, D. J. Tuma, H. C. Beckenhauer

Research output: Contribution to journalArticle

Abstract

This study demonstrated that fatty infiltration of the liver produced by a choline deficient diet is accompanied by a high degree of damage to the ammonia detoxification enzymes of the liver. Assays for arginase and ornithine transcarbamylase showed a marked loss of both enzymes in livers on a choline deficient diet. No change was observed in livers from animals on a high alcohol intake with an adequate diet. Neither the alcohol intake nor the choline deficient diet changed the levels of another enzyme involved in ammonia metabolism, glutamic dehydrogenase.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalDigestion
Volume2
Issue number4
DOIs
Publication statusPublished - Jan 1 1969

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Keywords

  • Alcoholic intoxication
  • Arginase
  • Choline deficiency
  • Enzyme tests
  • Liver cirrhosis experimental
  • Ornithine carbamoyl transferase
  • Rats

ASJC Scopus subject areas

  • Gastroenterology

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