Inflammatory thoughts about glioma gene therapy

Tammy Kielian, William F. Hickey

Research output: Contribution to journalShort survey

25 Citations (Scopus)

Abstract

Gene therapy for treatment of glioma often involves delivery of herpes simplex virus-1 thymidine kinase gene. A new study shows that this approach can induce chronic inflammation, and raises important questions about current adenoviral-based clinical trials (pages 1256-1263).

Original languageEnglish (US)
Pages (from-to)1237-1238
Number of pages2
JournalNature Medicine
Volume5
Issue number11
DOIs
StatePublished - Nov 1 1999

Fingerprint

Gene therapy
Thymidine Kinase
Human Herpesvirus 1
Viruses
Glioma
Genetic Therapy
Genes
Clinical Trials
Inflammation
Therapeutics
thymidine kinase 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Inflammatory thoughts about glioma gene therapy. / Kielian, Tammy; Hickey, William F.

In: Nature Medicine, Vol. 5, No. 11, 01.11.1999, p. 1237-1238.

Research output: Contribution to journalShort survey

Kielian, Tammy ; Hickey, William F. / Inflammatory thoughts about glioma gene therapy. In: Nature Medicine. 1999 ; Vol. 5, No. 11. pp. 1237-1238.
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