Inflammatory peripheral neuropathy following high dose chemotherapy and autologous bone marrow transplantation

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12 Citations (Scopus)

Abstract

A 40-year-old man with non-Hodgkin's lymphoma developed severe ascending sensorimotor neuropathy 10 days after treatment with high dose chemotherapy and autologous bone marrow rescue. The neuropathy had axonal plus demyelinating features on electrophysiological studies. Sural nerve biopsy showed heavy infiltration of the epineurium and endoneurium with mononuclear cells. The patient had no other evidence of graft-versus-host disease. He failed to respond to plasmapheresis but responded to high dose steroids.

Original languageEnglish (US)
Pages (from-to)305-306
Number of pages2
JournalBone marrow transplantation
Volume10
Issue number3
StatePublished - Jan 1 1992

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Autologous Transplantation
Peripheral Nervous System Diseases
Bone Marrow Transplantation
Peripheral Nerves
Drug Therapy
Sural Nerve
Plasmapheresis
Graft vs Host Disease
Non-Hodgkin's Lymphoma
Bone Marrow
Steroids
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

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title = "Inflammatory peripheral neuropathy following high dose chemotherapy and autologous bone marrow transplantation",
abstract = "A 40-year-old man with non-Hodgkin's lymphoma developed severe ascending sensorimotor neuropathy 10 days after treatment with high dose chemotherapy and autologous bone marrow rescue. The neuropathy had axonal plus demyelinating features on electrophysiological studies. Sural nerve biopsy showed heavy infiltration of the epineurium and endoneurium with mononuclear cells. The patient had no other evidence of graft-versus-host disease. He failed to respond to plasmapheresis but responded to high dose steroids.",
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AB - A 40-year-old man with non-Hodgkin's lymphoma developed severe ascending sensorimotor neuropathy 10 days after treatment with high dose chemotherapy and autologous bone marrow rescue. The neuropathy had axonal plus demyelinating features on electrophysiological studies. Sural nerve biopsy showed heavy infiltration of the epineurium and endoneurium with mononuclear cells. The patient had no other evidence of graft-versus-host disease. He failed to respond to plasmapheresis but responded to high dose steroids.

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