Inflammatory cell phenotypes in AAAs: Their role and potential as targets for therapy

Matthew A. Dale, Melissa K. Ruhlman, Bernard Timothy Baxter

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammatory cell infiltration. AAA is typically an asymptomatic disease and caused ≈15 000 deaths annually in the United States. Previous studies have examined both human and murine aortic tissue for the presence of various inflammatory cell types. Studies show that in both human and experimental AAAs, prominent inflammatory cell infiltration, such as CD4 + T cells and macrophages, occurs in the damaged aortic wall. These cells have the ability to undergo phenotypic modulation based on microenvironmental cues, potentially influencing disease progression. Proinflammatory CD4 + T cells and classically activated macrophages dominate the landscape of aortic infiltrates. The skew to proinflammatory phenotypes alters disease progression and plays a role in causing chronic inflammation. The local cytokine production and presence of inflammatory mediators, such as extracellular matrix breakdown products, influence the uneven balance of the inflammatory infiltrate phenotypes. Understanding and developing new strategies that target the proinflammatory phenotype could provide useful therapeutic targets for a disease with no current pharmacological intervention.

Original languageEnglish (US)
Pages (from-to)1746-1755
Number of pages10
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume35
Issue number8
DOIs
StatePublished - Aug 25 2015

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Abdominal Aortic Aneurysm
Phenotype
Disease Progression
Macrophages
T-Lymphocytes
Asymptomatic Diseases
Aptitude
Therapeutics
Cues
Extracellular Matrix
Pharmacology
Cytokines
Inflammation

Keywords

  • aneurysm
  • aorta
  • inflammation
  • lymphocytes
  • macrophages

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Inflammatory cell phenotypes in AAAs : Their role and potential as targets for therapy. / Dale, Matthew A.; Ruhlman, Melissa K.; Baxter, Bernard Timothy.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 35, No. 8, 25.08.2015, p. 1746-1755.

Research output: Contribution to journalArticle

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