Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco

Amr S. Soliman, Celina G. Kleer, Karima Mrad, Mehdi Karkouri, Sherif Omar, Hussein M. Khaled, Abdel Latif Benider, Farhat Ben Ayed, Saad S. Eissa, Mohab S. Eissa, Erin J. McSpadden, An Chi Lo, Kathy Toy, Elizabeth D. Kantor, Quin Xiao, Claire Hampton, Sofia D. Merajver

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87% vs. 50%, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ± SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) (P < 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P=0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalBreast Disease
Volume33
Issue number4
DOIs
StatePublished - Dec 1 2011

Fingerprint

Inflammatory Breast Neoplasms
Northern Africa
Morocco
Tunisia
Egypt
Breast Neoplasms
Embolism
Neoplasms
Epidemiologic Factors
Erythema
Edema

Keywords

  • Egypt
  • Inflammatory breast cancer
  • Morocco
  • North Africa
  • RhoC
  • Tunisia
  • tumor emboli

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Inflammatory breast cancer in North Africa : Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco. / Soliman, Amr S.; Kleer, Celina G.; Mrad, Karima; Karkouri, Mehdi; Omar, Sherif; Khaled, Hussein M.; Benider, Abdel Latif; Ayed, Farhat Ben; Eissa, Saad S.; Eissa, Mohab S.; McSpadden, Erin J.; Lo, An Chi; Toy, Kathy; Kantor, Elizabeth D.; Xiao, Quin; Hampton, Claire; Merajver, Sofia D.

In: Breast Disease, Vol. 33, No. 4, 01.12.2011, p. 159-169.

Research output: Contribution to journalArticle

Soliman, AS, Kleer, CG, Mrad, K, Karkouri, M, Omar, S, Khaled, HM, Benider, AL, Ayed, FB, Eissa, SS, Eissa, MS, McSpadden, EJ, Lo, AC, Toy, K, Kantor, ED, Xiao, Q, Hampton, C & Merajver, SD 2011, 'Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco', Breast Disease, vol. 33, no. 4, pp. 159-169. https://doi.org/10.3233/BD-2012-000337
Soliman, Amr S. ; Kleer, Celina G. ; Mrad, Karima ; Karkouri, Mehdi ; Omar, Sherif ; Khaled, Hussein M. ; Benider, Abdel Latif ; Ayed, Farhat Ben ; Eissa, Saad S. ; Eissa, Mohab S. ; McSpadden, Erin J. ; Lo, An Chi ; Toy, Kathy ; Kantor, Elizabeth D. ; Xiao, Quin ; Hampton, Claire ; Merajver, Sofia D. / Inflammatory breast cancer in North Africa : Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco. In: Breast Disease. 2011 ; Vol. 33, No. 4. pp. 159-169.
@article{e2e44a8d7179444388d8832d2a78d079,
title = "Inflammatory breast cancer in North Africa: Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco",
abstract = "Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87{\%} vs. 50{\%}, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ± SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) (P < 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P=0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations.",
keywords = "Egypt, Inflammatory breast cancer, Morocco, North Africa, RhoC, Tunisia, tumor emboli",
author = "Soliman, {Amr S.} and Kleer, {Celina G.} and Karima Mrad and Mehdi Karkouri and Sherif Omar and Khaled, {Hussein M.} and Benider, {Abdel Latif} and Ayed, {Farhat Ben} and Eissa, {Saad S.} and Eissa, {Mohab S.} and McSpadden, {Erin J.} and Lo, {An Chi} and Kathy Toy and Kantor, {Elizabeth D.} and Quin Xiao and Claire Hampton and Merajver, {Sofia D.}",
year = "2011",
month = "12",
day = "1",
doi = "10.3233/BD-2012-000337",
language = "English (US)",
volume = "33",
pages = "159--169",
journal = "Breast Disease",
issn = "0888-6008",
publisher = "IOS Press",
number = "4",

}

TY - JOUR

T1 - Inflammatory breast cancer in North Africa

T2 - Comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco

AU - Soliman, Amr S.

AU - Kleer, Celina G.

AU - Mrad, Karima

AU - Karkouri, Mehdi

AU - Omar, Sherif

AU - Khaled, Hussein M.

AU - Benider, Abdel Latif

AU - Ayed, Farhat Ben

AU - Eissa, Saad S.

AU - Eissa, Mohab S.

AU - McSpadden, Erin J.

AU - Lo, An Chi

AU - Toy, Kathy

AU - Kantor, Elizabeth D.

AU - Xiao, Quin

AU - Hampton, Claire

AU - Merajver, Sofia D.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87% vs. 50%, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ± SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) (P < 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P=0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations.

AB - Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC). Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Egyptian IBC tumors had the highest RhoC expression than Tunisians and Moroccan IBCs (87% vs. 50%, vs. 38.1, for the 3 countries, respectively). Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ± SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.001) and Tunisians (Mean ± SD: 3.4 ± 2.5 vs. 1.9 ± 2.0, respectively) (P < 0.01). There was no difference of emboli in Moroccan tumors (1.7 ± 1.2 vs. 1.8 ± 1.2 for IBC and non-IBC, respectively (P=0.66). This study illustrates that RhoC overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia. Tumors of Moroccans were significantly different from Egyptian and Tunisian tumors for RhoC expression and emboli. Future studies should focus on relating epidemiologic factors and clinical pictures to molecular features of IBC in these and other populations.

KW - Egypt

KW - Inflammatory breast cancer

KW - Morocco

KW - North Africa

KW - RhoC

KW - Tunisia

KW - tumor emboli

UR - http://www.scopus.com/inward/record.url?scp=84876219796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876219796&partnerID=8YFLogxK

U2 - 10.3233/BD-2012-000337

DO - 10.3233/BD-2012-000337

M3 - Article

C2 - 23001584

AN - SCOPUS:84876219796

VL - 33

SP - 159

EP - 169

JO - Breast Disease

JF - Breast Disease

SN - 0888-6008

IS - 4

ER -