Inflammatory bowel disease after liver transplantation: Risk factors for recurrence and de novo disease

R. C. Verdonk, G. Dijkstra, E. B. Haagsma, V. K. Shostrom, A. P. Van Den Berg, J. H. Kleibeuker, Alan Norman Langnas, D. L. Sudan

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD) is associated with primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) and can recur or develop de novo after orthotopic liver transplantation (OLT). The aim of this study was to investigate the incidence and severity of IBD after liver transplantation and to perform a multivariate analysis for possible risk factors. In this retrospective study, 91 patients transplanted for PSC or AIH, without prior colectomy, were included. Sixty patients were transplanted for PSC, 31 for AIH. IBD activity before and after OLT and other possible risk factors were analysed in a multivariate model. Forty-nine patients (54%) had IBD before OLT. Forty patients (44%) had active IBD after transplantation: recurrence in 32 and de novo in 8. Cumulative risk for IBD after OLT was 15, 39 and 54% after 1, 5 and 10 years, respectively. In 59% of patients with IBD prior to OLT the disease was more active after transplantation. Risk factors for recurrent disease were: symptoms at time of OLT, short interval of IBD before OLT and use of tacrolimus. 5-aminosalicylates were protective. A cytomegalovirus positive donor/negative recipient combination increased the risk for de novo IBD.

Original languageEnglish (US)
Pages (from-to)1422-1429
Number of pages8
JournalAmerican Journal of Transplantation
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2006

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Inflammatory Bowel Diseases
Liver Transplantation
Recurrence
Autoimmune Hepatitis
Sclerosing Cholangitis
Transplantation
Mesalamine
Colectomy
Tacrolimus
Cytomegalovirus
Liver Diseases
Multivariate Analysis
Retrospective Studies
Tissue Donors
Incidence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Verdonk, R. C., Dijkstra, G., Haagsma, E. B., Shostrom, V. K., Van Den Berg, A. P., Kleibeuker, J. H., ... Sudan, D. L. (2006). Inflammatory bowel disease after liver transplantation: Risk factors for recurrence and de novo disease. American Journal of Transplantation, 6(6), 1422-1429. https://doi.org/10.1111/j.1600-6143.2006.01333.x

Inflammatory bowel disease after liver transplantation : Risk factors for recurrence and de novo disease. / Verdonk, R. C.; Dijkstra, G.; Haagsma, E. B.; Shostrom, V. K.; Van Den Berg, A. P.; Kleibeuker, J. H.; Langnas, Alan Norman; Sudan, D. L.

In: American Journal of Transplantation, Vol. 6, No. 6, 01.06.2006, p. 1422-1429.

Research output: Contribution to journalArticle

Verdonk, RC, Dijkstra, G, Haagsma, EB, Shostrom, VK, Van Den Berg, AP, Kleibeuker, JH, Langnas, AN & Sudan, DL 2006, 'Inflammatory bowel disease after liver transplantation: Risk factors for recurrence and de novo disease', American Journal of Transplantation, vol. 6, no. 6, pp. 1422-1429. https://doi.org/10.1111/j.1600-6143.2006.01333.x
Verdonk, R. C. ; Dijkstra, G. ; Haagsma, E. B. ; Shostrom, V. K. ; Van Den Berg, A. P. ; Kleibeuker, J. H. ; Langnas, Alan Norman ; Sudan, D. L. / Inflammatory bowel disease after liver transplantation : Risk factors for recurrence and de novo disease. In: American Journal of Transplantation. 2006 ; Vol. 6, No. 6. pp. 1422-1429.
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