Infection Surveillance Protocol for a Multicountry Population-based Study in South Asia to Determine the Incidence, Etiology and Risk Factors for Infections among Young Infants of 0 to 59 Days Old

for the ANISA Methods Group

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Insufficient knowledge of the etiology and risk factors for community-acquired neonatal infection in low-income countries is a barrier to designing appropriate intervention strategies for these settings to reduce the burden and treatment of young infant infection. To address these gaps, we are conducting the Aetiology of Neonatal Infection in South Asia (ANISA) study among young infants in Bangladesh, India and Pakistan. The objectives of ANISA are to establish a comprehensive surveillance system for registering newborns in study catchment areas and collecting data on bacterial and viral etiology and associated risk factors for infections among young infants aged 0-59 days. Methods: We are conducting active surveillance in 1 peri-urban and 4 rural communities. During 2 years of surveillance, we expect to enroll an estimated 66,000 newborns within 7 days of their birth and to follow-up them until 59 days of age. Community health workers visit each young infant in the study area 3 times in the first week of life and once a week thereafter. During these visits, community health workers assess the newborns using a clinical algorithm and refer young infants with signs of suspected infection to health care facilities where study physicians reassess them and provide care if needed. On physician confirmation of suspected infection, blood and respiratory specimens are collected and tested to identify the etiologic agent. Conclusions: ANISA is one of the largest initiatives ever undertaken to understand the etiology of young infant infection in low-income countries. The data generated from this surveillance will help guide evidence-based decision making to improve health care in similar settings.

Original languageEnglish (US)
Pages (from-to)S9-S15
JournalPediatric Infectious Disease Journal
Volume35
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Incidence
Infection
Population
Newborn Infant
Delivery of Health Care
Physicians
Community-Acquired Infections
Bangladesh
Health Facilities
Pakistan
Rural Population
Respiratory Tract Infections
India
Decision Making
Parturition
Therapeutics

Keywords

  • ANISA
  • community-acquired
  • etiology
  • infection
  • neonatal
  • surveillance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{2948b1fca63d4d3d87bc44e65bf583fd,
title = "Infection Surveillance Protocol for a Multicountry Population-based Study in South Asia to Determine the Incidence, Etiology and Risk Factors for Infections among Young Infants of 0 to 59 Days Old",
abstract = "Background: Insufficient knowledge of the etiology and risk factors for community-acquired neonatal infection in low-income countries is a barrier to designing appropriate intervention strategies for these settings to reduce the burden and treatment of young infant infection. To address these gaps, we are conducting the Aetiology of Neonatal Infection in South Asia (ANISA) study among young infants in Bangladesh, India and Pakistan. The objectives of ANISA are to establish a comprehensive surveillance system for registering newborns in study catchment areas and collecting data on bacterial and viral etiology and associated risk factors for infections among young infants aged 0-59 days. Methods: We are conducting active surveillance in 1 peri-urban and 4 rural communities. During 2 years of surveillance, we expect to enroll an estimated 66,000 newborns within 7 days of their birth and to follow-up them until 59 days of age. Community health workers visit each young infant in the study area 3 times in the first week of life and once a week thereafter. During these visits, community health workers assess the newborns using a clinical algorithm and refer young infants with signs of suspected infection to health care facilities where study physicians reassess them and provide care if needed. On physician confirmation of suspected infection, blood and respiratory specimens are collected and tested to identify the etiologic agent. Conclusions: ANISA is one of the largest initiatives ever undertaken to understand the etiology of young infant infection in low-income countries. The data generated from this surveillance will help guide evidence-based decision making to improve health care in similar settings.",
keywords = "ANISA, community-acquired, etiology, infection, neonatal, surveillance",
author = "{for the ANISA Methods Group} and Islam, {Mohammad Shahidul} and Baqui, {Abdullah H.} and Zaidi, {Anita K.} and Bhutta, {Zulfiqar A.} and Pinaki Panigrahi and Anuradha Bose and Soofi, {Sajid B.} and Kazi, {Abdul Momin} and Mitra, {Dipak K.} and Rita Isaac and Pritish Nanda and Connor, {Nicholas E.} and Roth, {Daniel E.} and Qazi, {Shamim A.} and Arifeen, {Shams El} and Saha, {Samir K.}",
year = "2016",
month = "5",
day = "1",
doi = "10.1097/INF.0000000000001100",
language = "English (US)",
volume = "35",
pages = "S9--S15",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "5",

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TY - JOUR

T1 - Infection Surveillance Protocol for a Multicountry Population-based Study in South Asia to Determine the Incidence, Etiology and Risk Factors for Infections among Young Infants of 0 to 59 Days Old

AU - for the ANISA Methods Group

AU - Islam, Mohammad Shahidul

AU - Baqui, Abdullah H.

AU - Zaidi, Anita K.

AU - Bhutta, Zulfiqar A.

AU - Panigrahi, Pinaki

AU - Bose, Anuradha

AU - Soofi, Sajid B.

AU - Kazi, Abdul Momin

AU - Mitra, Dipak K.

AU - Isaac, Rita

AU - Nanda, Pritish

AU - Connor, Nicholas E.

AU - Roth, Daniel E.

AU - Qazi, Shamim A.

AU - Arifeen, Shams El

AU - Saha, Samir K.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Insufficient knowledge of the etiology and risk factors for community-acquired neonatal infection in low-income countries is a barrier to designing appropriate intervention strategies for these settings to reduce the burden and treatment of young infant infection. To address these gaps, we are conducting the Aetiology of Neonatal Infection in South Asia (ANISA) study among young infants in Bangladesh, India and Pakistan. The objectives of ANISA are to establish a comprehensive surveillance system for registering newborns in study catchment areas and collecting data on bacterial and viral etiology and associated risk factors for infections among young infants aged 0-59 days. Methods: We are conducting active surveillance in 1 peri-urban and 4 rural communities. During 2 years of surveillance, we expect to enroll an estimated 66,000 newborns within 7 days of their birth and to follow-up them until 59 days of age. Community health workers visit each young infant in the study area 3 times in the first week of life and once a week thereafter. During these visits, community health workers assess the newborns using a clinical algorithm and refer young infants with signs of suspected infection to health care facilities where study physicians reassess them and provide care if needed. On physician confirmation of suspected infection, blood and respiratory specimens are collected and tested to identify the etiologic agent. Conclusions: ANISA is one of the largest initiatives ever undertaken to understand the etiology of young infant infection in low-income countries. The data generated from this surveillance will help guide evidence-based decision making to improve health care in similar settings.

AB - Background: Insufficient knowledge of the etiology and risk factors for community-acquired neonatal infection in low-income countries is a barrier to designing appropriate intervention strategies for these settings to reduce the burden and treatment of young infant infection. To address these gaps, we are conducting the Aetiology of Neonatal Infection in South Asia (ANISA) study among young infants in Bangladesh, India and Pakistan. The objectives of ANISA are to establish a comprehensive surveillance system for registering newborns in study catchment areas and collecting data on bacterial and viral etiology and associated risk factors for infections among young infants aged 0-59 days. Methods: We are conducting active surveillance in 1 peri-urban and 4 rural communities. During 2 years of surveillance, we expect to enroll an estimated 66,000 newborns within 7 days of their birth and to follow-up them until 59 days of age. Community health workers visit each young infant in the study area 3 times in the first week of life and once a week thereafter. During these visits, community health workers assess the newborns using a clinical algorithm and refer young infants with signs of suspected infection to health care facilities where study physicians reassess them and provide care if needed. On physician confirmation of suspected infection, blood and respiratory specimens are collected and tested to identify the etiologic agent. Conclusions: ANISA is one of the largest initiatives ever undertaken to understand the etiology of young infant infection in low-income countries. The data generated from this surveillance will help guide evidence-based decision making to improve health care in similar settings.

KW - ANISA

KW - community-acquired

KW - etiology

KW - infection

KW - neonatal

KW - surveillance

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U2 - 10.1097/INF.0000000000001100

DO - 10.1097/INF.0000000000001100

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VL - 35

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JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

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