Infection of Human Gastrointestinal Cells by HIV-1

Mary Pat Moyer, Rachel I. Huot, Adolph Ramirez, Steven Joe, Monte S. Meltzer, Howard E. Gendelman

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.

Original languageEnglish (US)
Pages (from-to)1409-1415
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume6
Issue number12
DOIs
StatePublished - Dec 1990

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HIV-1
HIV
Intestinal Mucosa
Virus Replication
Infection
Monocytes
Epithelial Cells
Viruses
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Infection of Human Gastrointestinal Cells by HIV-1. / Moyer, Mary Pat; Huot, Rachel I.; Ramirez, Adolph; Joe, Steven; Meltzer, Monte S.; Gendelman, Howard E.

In: AIDS Research and Human Retroviruses, Vol. 6, No. 12, 12.1990, p. 1409-1415.

Research output: Contribution to journalArticle

Moyer, MP, Huot, RI, Ramirez, A, Joe, S, Meltzer, MS & Gendelman, HE 1990, 'Infection of Human Gastrointestinal Cells by HIV-1', AIDS Research and Human Retroviruses, vol. 6, no. 12, pp. 1409-1415. https://doi.org/10.1089/aid.1990.6.1409
Moyer, Mary Pat ; Huot, Rachel I. ; Ramirez, Adolph ; Joe, Steven ; Meltzer, Monte S. ; Gendelman, Howard E. / Infection of Human Gastrointestinal Cells by HIV-1. In: AIDS Research and Human Retroviruses. 1990 ; Vol. 6, No. 12. pp. 1409-1415.
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