29 Citations (Scopus)

Abstract

Infections occurring in liver transplant recipients result in significant morbidity and mortality. Factors influencing the frequency of posttransplant infections include pre-transplant nutritional status, latent viral infections, and the degree of immunosuppression used to modulate the immune response to the allograft. Infectious agents may be introduced into the patient via the allograft, through infusion of blood products, and through intravenous lines, catheters, and drains. Infections also develop as a result of reactivation of latent viruses or by overgrowth or invasion by endogenous organisms. The intensity of the immunosuppressive regimen directly affects the frequency of infection. Infection may be categorized as bacterial, viral, fungal, or protozoal. The most frequent organisms include bacterial-enterobacteriaceae; viral-cytomegalovirus; fungal-Candida species and Aspergillus species; and protozoal-Pneumocystis carinii. Diagnosing infection requires the use of many different methods in combination, including routine bacterial culture, viral culture, and fungal culture. Histologic and cytologic examination may lead to rapid identification of some organisms. Specialized collection procedures such as bronchoalveolar lavage provide rapid access to material for culture and cytologic examination. Serum serology in conjunction with histotopic or cytologic evaluation is useful in diagnosing some infections, such as Epstein-Barr virus. New technology such as polymerase chain reaction allows detection of all types of infection at or before the onset of clinical symptoms. Rapid and early diagnosis of infection in this patient population can reduce infection-related morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)64-78
Number of pages15
JournalAmerican Journal of Surgical Pathology
Volume14
Issue numberSUPPL. 1
StatePublished - Jan 1 1990

Fingerprint

Liver Transplantation
Infection
Allografts
Morbidity
Pneumocystis carinii
Mortality
Bronchoalveolar Lavage
Virus Diseases
Enterobacteriaceae
Serology
Aspergillus
Immunosuppressive Agents
Nutritional Status
Cytomegalovirus
Human Herpesvirus 4
Candida
Immunosuppression
Early Diagnosis
Catheters
Viruses

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Markin, R. S., Stratta, R. J., & Woods, G. L. (1990). Infection after liver transplantation. American Journal of Surgical Pathology, 14(SUPPL. 1), 64-78.

Infection after liver transplantation. / Markin, Rodney Smith; Stratta, R. J.; Woods, G. L.

In: American Journal of Surgical Pathology, Vol. 14, No. SUPPL. 1, 01.01.1990, p. 64-78.

Research output: Contribution to journalArticle

Markin, RS, Stratta, RJ & Woods, GL 1990, 'Infection after liver transplantation', American Journal of Surgical Pathology, vol. 14, no. SUPPL. 1, pp. 64-78.
Markin RS, Stratta RJ, Woods GL. Infection after liver transplantation. American Journal of Surgical Pathology. 1990 Jan 1;14(SUPPL. 1):64-78.
Markin, Rodney Smith ; Stratta, R. J. ; Woods, G. L. / Infection after liver transplantation. In: American Journal of Surgical Pathology. 1990 ; Vol. 14, No. SUPPL. 1. pp. 64-78.
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