Induction and prevention of squamous transformation of bronchial epithelial cells by phenolic compounds

R. N. Palmatier, T. Henry, S. I. Rennard, J. D. Beckmann

Research output: Contribution to journalArticle

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Abstract

1. The exposure of cultured bovine bronchial epithelial cells to 2- naphthol and catechol (10-100 μM) induced a squamous phenotype and inhibited cell proliferation. Phenol and cresol did not have these effects at up to 100 μM. 2. These effects occurred below cytotoxic levels and cell proliferation resumed subsequent to removal of the exposures. 3. Induction of the squamous phenotype was antagonized by retinoic acid, a known morphogenic hormone for several airway epithelial cell culture model systems. 4. Purified recombinant bovine phenol sulphotransferase was used to ablate the antiproliferative and squamous inductive effects of catechol on the cultured airway epithelial cells.

Original languageEnglish (US)
Pages (from-to)1201-1214
Number of pages14
JournalXenobiotica
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 1 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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