Induced pluripotent stem cells: What lies beyond the paradigm shift

Jesse L. Cox, A Angie Rizzino

Research output: Contribution to journalShort survey

44 Citations (Scopus)

Abstract

The discovery that somatic cells can be reprogrammed to become induced pluripotent stem (iPS) cells has ushered in a new and exciting era in regenerative medicine. Since the seminal discovery of somatic cell reprogramming by Takahashi and Yamanaka in 2006, there has been remarkable progress in the characterization of iPS cells and the protocols used to generate them. The new information generated during the past year alone has vastly expanded our understanding of these cells. Accordingly, this review provides a basic overview of the different strategies used to generate iPS cells and focuses on recent developments in the field of iPS cells. In the final section, we discuss three broad, unanswered questions related to somatic cell reprogramming, which are just starting to be addressed.

Original languageEnglish (US)
Pages (from-to)148-158
Number of pages11
JournalExperimental Biology and Medicine
Volume235
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Induced Pluripotent Stem Cells
Stem cells
Regenerative Medicine
Cellular Reprogramming

Keywords

  • Cell cycle
  • Chromatin remodeling
  • DNA methylation
  • Epigenetic
  • IPS cells
  • Induced pluripotent stem cells
  • Nanog
  • Oct4
  • Reprogramming
  • Sox2
  • X chromosome inactivation
  • mi-RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Induced pluripotent stem cells : What lies beyond the paradigm shift. / Cox, Jesse L.; Rizzino, A Angie.

In: Experimental Biology and Medicine, Vol. 235, No. 2, 01.02.2010, p. 148-158.

Research output: Contribution to journalShort survey

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