Increasing time on target: utilization of inhibitors of cysteine cathepsins to enhance the tumor retention of receptor-targeted agents

Wei Fan, Wenting Zhang, Sameer Alshehri, Jered C Garrison

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a strategy of utilizing irreversible cysteine cathepsin inhibitor as trapping agent to increase the tumor residence time of receptor-targeted agents. The targeted constructs incorporating these cysteine cathepsin trapping agents were able to form high molecular weight adducts with intracellular cysteine cathepsins, thus achieving superior retention in tumor tissues.

Original languageEnglish (US)
Pages (from-to)11268-11271
Number of pages4
JournalChemical Communications
Volume54
Issue number80
DOIs
StatePublished - Jan 1 2018

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Cathepsins
Cysteine
Tumors
Molecular weight
Tissue

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Increasing time on target : utilization of inhibitors of cysteine cathepsins to enhance the tumor retention of receptor-targeted agents. / Fan, Wei; Zhang, Wenting; Alshehri, Sameer; Garrison, Jered C.

In: Chemical Communications, Vol. 54, No. 80, 01.01.2018, p. 11268-11271.

Research output: Contribution to journalArticle

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