Increased Survival by Pulmonary Treatment of Established Lung Metastases with Dual STAT3/CXCR4 Inhibition by siRNA Nanoemulsions

Zhaoting Li, Gang Chen, Ling Ding, Yixin Wang, Chenfei Zhu, Kaikai Wang, Jing Li, Minjie Sun, David Oupicky

Research output: Contribution to journalArticle

Abstract

Li and colleagues report on the direct pulmonary delivery of combination treatments for lung metastases of breast cancer using nanoemulsion formulations of siRNA against STAT3 and an inhibitor of a chemokine receptor CXCR4. The authors show improved antitumor activity and survival of pulmonary delivery when compared with intravenous injection.

Original languageEnglish (US)
JournalMolecular Therapy
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Small Interfering RNA
Neoplasm Metastasis
Lung
Chemokine Receptors
Intravenous Injections
Therapeutics
Breast Neoplasms

Keywords

  • CXCR4
  • immune suppression
  • lung metastasis
  • nanoemulsion
  • perfluorocarbon
  • polyplex
  • pulmonary delivery
  • STAT3

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

Cite this

Increased Survival by Pulmonary Treatment of Established Lung Metastases with Dual STAT3/CXCR4 Inhibition by siRNA Nanoemulsions. / Li, Zhaoting; Chen, Gang; Ding, Ling; Wang, Yixin; Zhu, Chenfei; Wang, Kaikai; Li, Jing; Sun, Minjie; Oupicky, David.

In: Molecular Therapy, 01.01.2019.

Research output: Contribution to journalArticle

Li, Zhaoting ; Chen, Gang ; Ding, Ling ; Wang, Yixin ; Zhu, Chenfei ; Wang, Kaikai ; Li, Jing ; Sun, Minjie ; Oupicky, David. / Increased Survival by Pulmonary Treatment of Established Lung Metastases with Dual STAT3/CXCR4 Inhibition by siRNA Nanoemulsions. In: Molecular Therapy. 2019.
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