Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

Nina Sanapareddy, Ryan M. Legge, Biljana Jovov, Amber McCoy, Lauren Burcal, Felix Araujo-Perez, Thomas A. Randall, Joseph Galanko, Andrew K Benson, Robert S. Sandler, John F. Rawls, Zaid Abdo, Anthony A. Fodor, Temitope O. Keku

Research output: Contribution to journalArticle

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Abstract

Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohns disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.

Original languageEnglish (US)
Pages (from-to)1858-1868
Number of pages11
JournalISME Journal
Volume6
Issue number10
DOIs
StatePublished - Oct 1 2012

Fingerprint

obesity
adenoma
Adenoma
cancer
titanium
microbial community
colorectal neoplasms
intestinal microorganisms
diet
biopsy
Colorectal Neoplasms
Obesity
bacterium
gene
Biopsy
diet history
Crohn disease
Microbiota
colitis
Titanium

Keywords

  • BMI
  • Colon cancer
  • Commensal bacteria
  • Diagnostic

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Sanapareddy, N., Legge, R. M., Jovov, B., McCoy, A., Burcal, L., Araujo-Perez, F., ... Keku, T. O. (2012). Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. ISME Journal, 6(10), 1858-1868. https://doi.org/10.1038/ismej.2012.43

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. / Sanapareddy, Nina; Legge, Ryan M.; Jovov, Biljana; McCoy, Amber; Burcal, Lauren; Araujo-Perez, Felix; Randall, Thomas A.; Galanko, Joseph; Benson, Andrew K; Sandler, Robert S.; Rawls, John F.; Abdo, Zaid; Fodor, Anthony A.; Keku, Temitope O.

In: ISME Journal, Vol. 6, No. 10, 01.10.2012, p. 1858-1868.

Research output: Contribution to journalArticle

Sanapareddy, N, Legge, RM, Jovov, B, McCoy, A, Burcal, L, Araujo-Perez, F, Randall, TA, Galanko, J, Benson, AK, Sandler, RS, Rawls, JF, Abdo, Z, Fodor, AA & Keku, TO 2012, 'Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans', ISME Journal, vol. 6, no. 10, pp. 1858-1868. https://doi.org/10.1038/ismej.2012.43
Sanapareddy N, Legge RM, Jovov B, McCoy A, Burcal L, Araujo-Perez F et al. Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. ISME Journal. 2012 Oct 1;6(10):1858-1868. https://doi.org/10.1038/ismej.2012.43
Sanapareddy, Nina ; Legge, Ryan M. ; Jovov, Biljana ; McCoy, Amber ; Burcal, Lauren ; Araujo-Perez, Felix ; Randall, Thomas A. ; Galanko, Joseph ; Benson, Andrew K ; Sandler, Robert S. ; Rawls, John F. ; Abdo, Zaid ; Fodor, Anthony A. ; Keku, Temitope O. / Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. In: ISME Journal. 2012 ; Vol. 6, No. 10. pp. 1858-1868.
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