Increased norepinephrine turnover in the median preoptic nucleus following reduced extracellular fluid volume

L. D. Wilkin, K. P. Patel, P. G. Schmid, A. K. Johnson

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The role of noradrenergic input to fluid balance regulatory systems in the anterior hypothalamus was studied by examination of norepinephrine (NE) turnover during reduction of systemic extracellular fluid volume. Extracellular fluid volume was decreased iso-os-motically by subcutaneous polyethylene glycol (PEG), known to increase thirst and vasopressin secretion. NE turnover was assessed by measuring the decline of NE concentration in brain micropunches after administration of α-methyl tyrosine in PEG- or shamtreated groups. Several hypothalamic areas were investigated, including the median preoptic area (MnPO), preoptic area (POA), paraventricular nucleus, supraoptic nucleus (SON), subfornical organ, ventromedial hypothalamus, and posterior hypothalamus. Volume-depleted animals showed significantly increased NE turnover in the MnPO, an important area for integration of fluod balance information. The POA and the SON also showed trends toward increased NE turnover. All other areas showed no difference in NE turnover between volume-depleted and normal animals. These results are consistent with previous findings that NE innervation to the MnPO is important in the control of fluid balance and also support the hypothesis that basal forebrain NE projections facilitate thirst and vasopressin secretion.

Original languageEnglish (US)
Pages (from-to)369-372
Number of pages4
JournalBrain Research
Volume423
Issue number1-2
DOIs
StatePublished - Oct 13 1987

Fingerprint

Preoptic Area
Extracellular Fluid
Norepinephrine
Thirst
Supraoptic Nucleus
Water-Electrolyte Balance
Vasopressins
Subfornical Organ
Posterior Hypothalamus
Anterior Hypothalamus
Paraventricular Hypothalamic Nucleus
Hypothalamus
Tyrosine
Brain

Keywords

  • Fluid balance
  • Hypothalamus
  • Lamina terminalis
  • Median preoptic nucleus
  • Norepinephrine
  • Supraoptic nucleus
  • Vasopressin
  • α-Methyl tyrosine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Increased norepinephrine turnover in the median preoptic nucleus following reduced extracellular fluid volume. / Wilkin, L. D.; Patel, K. P.; Schmid, P. G.; Johnson, A. K.

In: Brain Research, Vol. 423, No. 1-2, 13.10.1987, p. 369-372.

Research output: Contribution to journalArticle

Wilkin, L. D. ; Patel, K. P. ; Schmid, P. G. ; Johnson, A. K. / Increased norepinephrine turnover in the median preoptic nucleus following reduced extracellular fluid volume. In: Brain Research. 1987 ; Vol. 423, No. 1-2. pp. 369-372.
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