Increased left atrial pressure does not alter renal function in the conscious primate

K. G. Cornish, J. P. Gilmore

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To study the functional role of the atriorenal reflex in the nonhuman primate, we chronically instrumented six Macaca fascicularis with left atrial snares and left atrial and aortic catheters. After inserting a bladder catheter, we determined hemodynamic and renal response of the conscious chair-restrained monkey to increased left atrial pressure. In 23 snare experiments, no significant changes in renal or cardiovascular function were observed even though left atrial pressure increased from 6.5 ± 3.3 to 16.2 ± 3.4 mmHg. The animals were subjected also to blood volume expansion with isoncotic isotonic dextran solutions (+15% of calculated blood volume). They responded normally to this volume stimulus. Conscious dogs prepared in the same manner as the nonhuman primate exhibited diuresis in response to elevations of atrial pressure. We conclude that left atrial stretch receptors are not importantly involved in volume homeostasis in the nonhman primate.

Original languageEnglish (US)
Pages (from-to)R119-R124
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume12
Issue number1
StatePublished - Jan 1 1982

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Atrial Pressure
Primates
Blood Volume
Kidney
Catheters
Isotonic Solutions
Mechanoreceptors
Macaca fascicularis
Diuresis
Dextrans
Haplorhini
Reflex
Urinary Bladder
Homeostasis
Hemodynamics
Dogs

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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Increased left atrial pressure does not alter renal function in the conscious primate. / Cornish, K. G.; Gilmore, J. P.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 12, No. 1, 01.01.1982, p. R119-R124.

Research output: Contribution to journalArticle

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