Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis

Francis M. Giardiello, Audrey J Lazenby, John H. Yardley, Wilma B. Bias, James Johnson, Robert G. Alianiello, Marshall S. Bedine, Theodore M. Bayless

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Lymphocytic colitis is a newly described chronic diarrheal disorder. Although its etiology is unknown, the possibility has been raised that autoimmunity may play a role in both lymphocytic and collagenous colitis, a similar clinicopathologic illness. The frequencies of HLA class I and class II antigens were examined in 24 white patients with lymphocytic colitis and in 47 white patients with collagenous colitis. Frequencies in these two disorders were compared to control white populations and to each other. An increased frequency of HLA-A1 was noted in 16 of 24 lymphocytic colitis patients (66.6%) compared with 1089 of 3942 controls (27.6%) (P<0.005; relative risk 5.2). Furthermore, HLA-A3 was found in decreased frequency in lymphocytic colitis patients: 0 of 24 (0%) compared with 1017 of 3942 controls (25.8%) (P<0.05; relative risk 0.0). Collagenous colitis patients had no significant deviation from control frequencies of HLA antigens. In lymphocytic colitis, there was no significant increase in B8 or DR3 antigens, which are found in linkage disequilibrium with A1 and associated with many autoimmune diseases. Moreover, the frequency of autoimmune-associated class I HLA antigens was not increased in lymphocytic colitis. Statistically significant differences existed between lymphocytic and collagenous colitis in HLA-A1, A3, Bw6, and B7 antigen frequencies. The HLA patterns noted previously in other gastrointestinal disorders, including ulcerative colitis and Crohn's disease, were not apparent in lymphocytic or collagenous colitis. HLA typing provides further evidence that lymphocytic colitis is a distinct form of chronic intestinal inflammatory disease associated with HLA class I phenotypes.

Original languageEnglish (US)
Pages (from-to)496-499
Number of pages4
JournalDigestive Diseases and Sciences
Volume37
Issue number4
DOIs
StatePublished - Apr 1 1992

Fingerprint

Lymphocytic Colitis
HLA-A3 Antigen
HLA-A1 Antigen
Collagenous Colitis
HLA Antigens
B7 Antigens
Intestinal Diseases
Histocompatibility Testing
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Linkage Disequilibrium
Autoimmunity
Ulcerative Colitis
Crohn Disease
Autoimmune Diseases

Keywords

  • HLA
  • collagenous colitis
  • histocompatibility antigens
  • inflammatory bowel disease
  • lymphocytic colitis

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. / Giardiello, Francis M.; Lazenby, Audrey J; Yardley, John H.; Bias, Wilma B.; Johnson, James; Alianiello, Robert G.; Bedine, Marshall S.; Bayless, Theodore M.

In: Digestive Diseases and Sciences, Vol. 37, No. 4, 01.04.1992, p. 496-499.

Research output: Contribution to journalArticle

Giardiello, FM, Lazenby, AJ, Yardley, JH, Bias, WB, Johnson, J, Alianiello, RG, Bedine, MS & Bayless, TM 1992, 'Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis', Digestive Diseases and Sciences, vol. 37, no. 4, pp. 496-499. https://doi.org/10.1007/BF01307569
Giardiello, Francis M. ; Lazenby, Audrey J ; Yardley, John H. ; Bias, Wilma B. ; Johnson, James ; Alianiello, Robert G. ; Bedine, Marshall S. ; Bayless, Theodore M. / Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. In: Digestive Diseases and Sciences. 1992 ; Vol. 37, No. 4. pp. 496-499.
@article{a5c90e8b0b71471e9b211413bb6b80b1,
title = "Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis",
abstract = "Lymphocytic colitis is a newly described chronic diarrheal disorder. Although its etiology is unknown, the possibility has been raised that autoimmunity may play a role in both lymphocytic and collagenous colitis, a similar clinicopathologic illness. The frequencies of HLA class I and class II antigens were examined in 24 white patients with lymphocytic colitis and in 47 white patients with collagenous colitis. Frequencies in these two disorders were compared to control white populations and to each other. An increased frequency of HLA-A1 was noted in 16 of 24 lymphocytic colitis patients (66.6{\%}) compared with 1089 of 3942 controls (27.6{\%}) (P<0.005; relative risk 5.2). Furthermore, HLA-A3 was found in decreased frequency in lymphocytic colitis patients: 0 of 24 (0{\%}) compared with 1017 of 3942 controls (25.8{\%}) (P<0.05; relative risk 0.0). Collagenous colitis patients had no significant deviation from control frequencies of HLA antigens. In lymphocytic colitis, there was no significant increase in B8 or DR3 antigens, which are found in linkage disequilibrium with A1 and associated with many autoimmune diseases. Moreover, the frequency of autoimmune-associated class I HLA antigens was not increased in lymphocytic colitis. Statistically significant differences existed between lymphocytic and collagenous colitis in HLA-A1, A3, Bw6, and B7 antigen frequencies. The HLA patterns noted previously in other gastrointestinal disorders, including ulcerative colitis and Crohn's disease, were not apparent in lymphocytic or collagenous colitis. HLA typing provides further evidence that lymphocytic colitis is a distinct form of chronic intestinal inflammatory disease associated with HLA class I phenotypes.",
keywords = "HLA, collagenous colitis, histocompatibility antigens, inflammatory bowel disease, lymphocytic colitis",
author = "Giardiello, {Francis M.} and Lazenby, {Audrey J} and Yardley, {John H.} and Bias, {Wilma B.} and James Johnson and Alianiello, {Robert G.} and Bedine, {Marshall S.} and Bayless, {Theodore M.}",
year = "1992",
month = "4",
day = "1",
doi = "10.1007/BF01307569",
language = "English (US)",
volume = "37",
pages = "496--499",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis

AU - Giardiello, Francis M.

AU - Lazenby, Audrey J

AU - Yardley, John H.

AU - Bias, Wilma B.

AU - Johnson, James

AU - Alianiello, Robert G.

AU - Bedine, Marshall S.

AU - Bayless, Theodore M.

PY - 1992/4/1

Y1 - 1992/4/1

N2 - Lymphocytic colitis is a newly described chronic diarrheal disorder. Although its etiology is unknown, the possibility has been raised that autoimmunity may play a role in both lymphocytic and collagenous colitis, a similar clinicopathologic illness. The frequencies of HLA class I and class II antigens were examined in 24 white patients with lymphocytic colitis and in 47 white patients with collagenous colitis. Frequencies in these two disorders were compared to control white populations and to each other. An increased frequency of HLA-A1 was noted in 16 of 24 lymphocytic colitis patients (66.6%) compared with 1089 of 3942 controls (27.6%) (P<0.005; relative risk 5.2). Furthermore, HLA-A3 was found in decreased frequency in lymphocytic colitis patients: 0 of 24 (0%) compared with 1017 of 3942 controls (25.8%) (P<0.05; relative risk 0.0). Collagenous colitis patients had no significant deviation from control frequencies of HLA antigens. In lymphocytic colitis, there was no significant increase in B8 or DR3 antigens, which are found in linkage disequilibrium with A1 and associated with many autoimmune diseases. Moreover, the frequency of autoimmune-associated class I HLA antigens was not increased in lymphocytic colitis. Statistically significant differences existed between lymphocytic and collagenous colitis in HLA-A1, A3, Bw6, and B7 antigen frequencies. The HLA patterns noted previously in other gastrointestinal disorders, including ulcerative colitis and Crohn's disease, were not apparent in lymphocytic or collagenous colitis. HLA typing provides further evidence that lymphocytic colitis is a distinct form of chronic intestinal inflammatory disease associated with HLA class I phenotypes.

AB - Lymphocytic colitis is a newly described chronic diarrheal disorder. Although its etiology is unknown, the possibility has been raised that autoimmunity may play a role in both lymphocytic and collagenous colitis, a similar clinicopathologic illness. The frequencies of HLA class I and class II antigens were examined in 24 white patients with lymphocytic colitis and in 47 white patients with collagenous colitis. Frequencies in these two disorders were compared to control white populations and to each other. An increased frequency of HLA-A1 was noted in 16 of 24 lymphocytic colitis patients (66.6%) compared with 1089 of 3942 controls (27.6%) (P<0.005; relative risk 5.2). Furthermore, HLA-A3 was found in decreased frequency in lymphocytic colitis patients: 0 of 24 (0%) compared with 1017 of 3942 controls (25.8%) (P<0.05; relative risk 0.0). Collagenous colitis patients had no significant deviation from control frequencies of HLA antigens. In lymphocytic colitis, there was no significant increase in B8 or DR3 antigens, which are found in linkage disequilibrium with A1 and associated with many autoimmune diseases. Moreover, the frequency of autoimmune-associated class I HLA antigens was not increased in lymphocytic colitis. Statistically significant differences existed between lymphocytic and collagenous colitis in HLA-A1, A3, Bw6, and B7 antigen frequencies. The HLA patterns noted previously in other gastrointestinal disorders, including ulcerative colitis and Crohn's disease, were not apparent in lymphocytic or collagenous colitis. HLA typing provides further evidence that lymphocytic colitis is a distinct form of chronic intestinal inflammatory disease associated with HLA class I phenotypes.

KW - HLA

KW - collagenous colitis

KW - histocompatibility antigens

KW - inflammatory bowel disease

KW - lymphocytic colitis

UR - http://www.scopus.com/inward/record.url?scp=0026520061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026520061&partnerID=8YFLogxK

U2 - 10.1007/BF01307569

DO - 10.1007/BF01307569

M3 - Article

VL - 37

SP - 496

EP - 499

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 4

ER -