Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in kleine-levin syndrome

Rodney K. Koerber, Richard Torkelson, Guy Haven, John Donaldson, Samuel Monroe Cohen, Mary Case

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

A 17-year-old man with the Kleine-Levin syndrome died unexpectedly of cardiopulmonary arrest during a period of autonomic instability that followed an episode of megaphagia. At autopsy, the only pertinent finding was mild depigmentation of the locus ceruleus and sub -1 stantia nigra. Premortem CSF levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels were elevated. These findings I indicate that many symptoms of the Kleine-Levin syndrome are a result of a neurotransmitter imbalance in the serotonergic pathway of the brainstem.

Original languageEnglish (US)
Pages (from-to)1597-1600
Number of pages4
JournalNeurology
Volume34
Issue number12
StatePublished - Dec 1984

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Kleine-Levin Syndrome
Hydroxyindoleacetic Acid
Cerebrospinal Fluid
Serotonin
Locus Coeruleus
Heart Arrest
Brain Stem
Neurotransmitter Agents
Autopsy
Syndrome

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Koerber, R. K., Torkelson, R., Haven, G., Donaldson, J., Cohen, S. M., & Case, M. (1984). Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in kleine-levin syndrome. Neurology, 34(12), 1597-1600.

Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in kleine-levin syndrome. / Koerber, Rodney K.; Torkelson, Richard; Haven, Guy; Donaldson, John; Cohen, Samuel Monroe; Case, Mary.

In: Neurology, Vol. 34, No. 12, 12.1984, p. 1597-1600.

Research output: Contribution to journalArticle

Koerber, RK, Torkelson, R, Haven, G, Donaldson, J, Cohen, SM & Case, M 1984, 'Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in kleine-levin syndrome', Neurology, vol. 34, no. 12, pp. 1597-1600.
Koerber RK, Torkelson R, Haven G, Donaldson J, Cohen SM, Case M. Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in kleine-levin syndrome. Neurology. 1984 Dec;34(12):1597-1600.
Koerber, Rodney K. ; Torkelson, Richard ; Haven, Guy ; Donaldson, John ; Cohen, Samuel Monroe ; Case, Mary. / Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in kleine-levin syndrome. In: Neurology. 1984 ; Vol. 34, No. 12. pp. 1597-1600.
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