Increased Amygdala Activity During Successful Memory Encoding in Adolescent Major Depressive Disorder: An fMRI Study

Roxann Roberson-Nay, Erin B. McClure, Christopher S. Monk, Eric E. Nelson, Amanda E. Guyer, Stephen J. Fromm, Dennis S. Charney, Ellen Leibenluft, James Blair, Monique Ernst, Daniel S. Pine

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Background: Although major depressive disorder (MDD) represents one of the most serious psychiatric problems afflicting adolescents, efforts to understand the neural circuitry of adolescent MDD have lagged behind those of adult MDD. This study tests the hypothesis that adolescent MDD is associated with abnormal amygdala activity during evocative-face viewing. Methods: Using functional magnetic resonance imaging (fMRI), between-group differences among MDD (n = 10), anxious (n = 11), and non-psychiatric comparisons (n = 23) were examined during successful vs. unsuccessful face encoding, with encoding success measured post-scan. Results: Compared to healthy adolescents, MDD patients exhibited poorer memory for faces. fMRI analyses accounted for this performance difference through event-related methods. In an analysis comparing successful vs. unsuccessful face encoding, MDD patients exhibited greater left amygdala activation relative to healthy and anxious youth. Conclusions: Given prior findings among adults, this study suggests that adolescent and adult MDD may involve similar underlying abnormalities in amygdala functioning.

Original languageEnglish (US)
Pages (from-to)966-973
Number of pages8
JournalBiological Psychiatry
Volume60
Issue number9
DOIs
StatePublished - Nov 1 2006

Fingerprint

Major Depressive Disorder
Amygdala
Magnetic Resonance Imaging
Psychiatry

Keywords

  • Amygdala
  • MDD
  • anxiety
  • encoding
  • fMRI
  • recognition memory

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Roberson-Nay, R., McClure, E. B., Monk, C. S., Nelson, E. E., Guyer, A. E., Fromm, S. J., ... Pine, D. S. (2006). Increased Amygdala Activity During Successful Memory Encoding in Adolescent Major Depressive Disorder: An fMRI Study. Biological Psychiatry, 60(9), 966-973. https://doi.org/10.1016/j.biopsych.2006.02.018

Increased Amygdala Activity During Successful Memory Encoding in Adolescent Major Depressive Disorder : An fMRI Study. / Roberson-Nay, Roxann; McClure, Erin B.; Monk, Christopher S.; Nelson, Eric E.; Guyer, Amanda E.; Fromm, Stephen J.; Charney, Dennis S.; Leibenluft, Ellen; Blair, James; Ernst, Monique; Pine, Daniel S.

In: Biological Psychiatry, Vol. 60, No. 9, 01.11.2006, p. 966-973.

Research output: Contribution to journalArticle

Roberson-Nay, R, McClure, EB, Monk, CS, Nelson, EE, Guyer, AE, Fromm, SJ, Charney, DS, Leibenluft, E, Blair, J, Ernst, M & Pine, DS 2006, 'Increased Amygdala Activity During Successful Memory Encoding in Adolescent Major Depressive Disorder: An fMRI Study', Biological Psychiatry, vol. 60, no. 9, pp. 966-973. https://doi.org/10.1016/j.biopsych.2006.02.018
Roberson-Nay, Roxann ; McClure, Erin B. ; Monk, Christopher S. ; Nelson, Eric E. ; Guyer, Amanda E. ; Fromm, Stephen J. ; Charney, Dennis S. ; Leibenluft, Ellen ; Blair, James ; Ernst, Monique ; Pine, Daniel S. / Increased Amygdala Activity During Successful Memory Encoding in Adolescent Major Depressive Disorder : An fMRI Study. In: Biological Psychiatry. 2006 ; Vol. 60, No. 9. pp. 966-973.
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