Increase in the relative abundance of preproenkephalin A messenger RNA in the ventricles of cardiomyopathic hamsters

Michel M Ouellette, Léa Brakier-Gingras

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Preproenkephalin A messenger RNA was detected in hamster heart by Northern blot analysis using a human preproenkephalin A cDNA probe. Ventricular levels of this messenger were one order of magnitude lower than atrial levels, which were equivalent to brain levels. Furthermore, in the heart of cardiomyopathic hamsters, an animal model of cardiac hypertrophy and congestive heart failure, the relative abundance of the preproenkephalin A messenger RNA was found to increase three- to four-fold in ventricles while no change was seen in atria. These results support the hypothesis that the heart has the potential for locally synthesizing enkephalins and provide evidence that alterations in preproenkephalin A messenger RNA levels are associated with the development of cardiac hypertrophy and failure.

Original languageEnglish (US)
Pages (from-to)449-454
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume155
Issue number1
DOIs
StatePublished - Aug 30 1988

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Cricetinae
Messenger RNA
Cardiomegaly
Heart Failure
Enkephalins
Northern Blotting
Brain
Animals
Animal Models
Complementary DNA
preproenkephalin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Increase in the relative abundance of preproenkephalin A messenger RNA in the ventricles of cardiomyopathic hamsters. / Ouellette, Michel M; Brakier-Gingras, Léa.

In: Biochemical and Biophysical Research Communications, Vol. 155, No. 1, 30.08.1988, p. 449-454.

Research output: Contribution to journalArticle

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