Including colon in intestinal transplantation: a focus on post-transplant renal function – a retrospective study

Cale Ewald, Benjamin J. Swanson, Luciano Vargas, Wendy J. Grant, David F. Mercer, Alan N. Langnas, Shaheed Merani

Research output: Contribution to journalArticle

Abstract

Intestinal transplant recipients experience a high rate of renal complications secondary to dehydration due to increased ostomy output. It is hypothesized that inclusion of donor colon in the intestinal allograft may improve renal function in patients without functional native colon by improving fluid absorption. A single-center retrospective study of intestinal transplant recipients compared outcomes of patients receiving en bloc colon as part an intestinal allograft (ICTx), and those not receiving colon (CCNTx), as well as a control group of intestinal transplant recipients with functional native colon (ITx). Forty-seven patients (ICTx n = 17, CCNTx n = 15, ITx n = 15) were studied. One-year post-transplant renal function, as measured by change in glomerular filtration rate (GFR) and blood urea nitrogen (BUN) from baseline, was superior in ICTx (mean delta-GFR of −1.31 and delta-BUN of −1.46) compared to CCNTx (−6.54 and 17.54, P = 0.05 and P = 0.17, respectively) and similar to the ITx controls (0.55 and 2.09). Recipients of donor colon experienced a higher rate of ileostomy reversal when compared to CCNTx (62.5% vs. 20%, P = 0.0008), which was similar to the ITx controls (60%). These findings support the inclusion of en bloc donor colon in the intestinal allograft for recipients without functional native colon.

Original languageEnglish (US)
JournalTransplant International
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Colon
Retrospective Studies
Transplantation
Transplants
Kidney
Allografts
Blood Urea Nitrogen
Tissue Donors
Glomerular Filtration Rate
Ostomy
Ileostomy
Dehydration
Control Groups
Transplant Recipients

Keywords

  • colon transplant
  • intestinal transplant
  • renal function

ASJC Scopus subject areas

  • Transplantation

Cite this

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title = "Including colon in intestinal transplantation: a focus on post-transplant renal function – a retrospective study",
abstract = "Intestinal transplant recipients experience a high rate of renal complications secondary to dehydration due to increased ostomy output. It is hypothesized that inclusion of donor colon in the intestinal allograft may improve renal function in patients without functional native colon by improving fluid absorption. A single-center retrospective study of intestinal transplant recipients compared outcomes of patients receiving en bloc colon as part an intestinal allograft (ICTx), and those not receiving colon (CCNTx), as well as a control group of intestinal transplant recipients with functional native colon (ITx). Forty-seven patients (ICTx n = 17, CCNTx n = 15, ITx n = 15) were studied. One-year post-transplant renal function, as measured by change in glomerular filtration rate (GFR) and blood urea nitrogen (BUN) from baseline, was superior in ICTx (mean delta-GFR of −1.31 and delta-BUN of −1.46) compared to CCNTx (−6.54 and 17.54, P = 0.05 and P = 0.17, respectively) and similar to the ITx controls (0.55 and 2.09). Recipients of donor colon experienced a higher rate of ileostomy reversal when compared to CCNTx (62.5{\%} vs. 20{\%}, P = 0.0008), which was similar to the ITx controls (60{\%}). These findings support the inclusion of en bloc donor colon in the intestinal allograft for recipients without functional native colon.",
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AU - Ewald, Cale

AU - Swanson, Benjamin J.

AU - Vargas, Luciano

AU - Grant, Wendy J.

AU - Mercer, David F.

AU - Langnas, Alan N.

AU - Merani, Shaheed

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