Inability of chronic alcoholics with liver disease to use food as a source of folates, thiamin and vitamin B 6

H. Baker, O. Frank, Rowen K Zetterman, K. S. Rajan, W. ten Hove, C. M. Leevy

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Absorption of folates, thiamin, vitamin B 6, pantothenate and riboflavin from a natural food source - yeast - and their respective synthetic forms was studied in 36 patients with liver disease due to alcoholism, and 12 healthy, nonalcoholic subjects. All alcoholics absorbed riboflavin and pantothenate but had a significantly lowered absorption of thiamin and vitamin B 6 from yeast. Alcoholics absorbed synthetic vitamin B 6 but not thiamin. Ingested folylpolyglutamates (the predominant folates in yeast) could not serve as a source of folate for the alcoholics, but synthetic folylmonoglutamate served. It was suggested that the folate, vitamin B 6 and thiamin deficits so common in alcoholic liver disease ensue from inability to absorb these specific vitamins from foods.

Original languageEnglish (US)
Pages (from-to)1377-1380
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Volume28
Issue number12
StatePublished - Dec 1 1975

Fingerprint

Alcoholic Liver Diseases
Vitamin B 6
Thiamine
liver diseases
pyridoxine
alcohol abuse
thiamin
Folic Acid
folic acid
Alcoholics
Food
Riboflavin
Yeasts
riboflavin
yeasts
Vitamins
Alcoholism
natural foods
Liver Diseases
Healthy Volunteers

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Inability of chronic alcoholics with liver disease to use food as a source of folates, thiamin and vitamin B 6 . / Baker, H.; Frank, O.; Zetterman, Rowen K; Rajan, K. S.; ten Hove, W.; Leevy, C. M.

In: American Journal of Clinical Nutrition, Vol. 28, No. 12, 01.12.1975, p. 1377-1380.

Research output: Contribution to journalArticle

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