In Vivo tumor interstitial fluid pressure measurement using static micro force sensor and mechanical tumor model

Zhiyong Sun, Ruiguo Yang, Pavlo Kovalenko, Bo Song, Liangliang Chen, Mary F. Walsh, Lina Hao, Marc D. Basson, Ning Xi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The interstitial fluid pressure (IFP) plays a major role in tumor formation. Increased IFP may hinder the tran-scapillary transport of therapeutic agents as well as the large molecules, and may also lead to a poor prognosis for some cancer patients. IFP may therefore be an important biomarker. Serial noninvasive IFP measurement in vivo may facilitate drug development, if quantitative IFP data could be used for comparison. This paper proposes a novel technique employing a drift-compensated numerical Polyvinylidene Fluoride (PVDF) micro-force sensor and a load-deformation mechanical model of tumor to estimate the IFP. Experiments are carried out to verify the feasibility of the method and convincing data show its potential for in vivo tumor pressure measurement.

Original languageEnglish (US)
Title of host publicationAIM 2014 - IEEE/ASME International Conference on Advanced Intelligent Mechatronics
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages587-592
Number of pages6
ISBN (Print)9781479957361
DOIs
Publication statusPublished - Jan 1 2014
Event2014 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2014 - Besancon, France
Duration: Jul 8 2014Jul 11 2014

Publication series

NameIEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM

Other

Other2014 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2014
CountryFrance
CityBesancon
Period7/8/147/11/14

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ASJC Scopus subject areas

  • Control and Systems Engineering
  • Software
  • Computer Science Applications
  • Electrical and Electronic Engineering

Cite this

Sun, Z., Yang, R., Kovalenko, P., Song, B., Chen, L., Walsh, M. F., ... Xi, N. (2014). In Vivo tumor interstitial fluid pressure measurement using static micro force sensor and mechanical tumor model. In AIM 2014 - IEEE/ASME International Conference on Advanced Intelligent Mechatronics (pp. 587-592). [6878142] (IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/AIM.2014.6878142