In Vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci

Luke D. Handke, Mark Edmund Rupp

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Over billions of years of evolution, bacteria have developed a very successful mode of survival that has recently been characterized as the “biofilm phenotype.” In nature, opposed to existing in a free-floating planktonic form, the vast majority of bacteria are found attached to solid strata in structured communities encased in a self-produced polymeric matrix. This preferential, biofilm-associated means of bacterial growth has been recently defined by Donlan and Costerton as “a microbially derived sessile community characterized by cells that are irreversibly attached to a substratum or interface or to each other, are embedded in a matrix of extracellular polymeric substances that they have produced, and exhibit an altered phenotype with respect to growth rate and gene transcription” (1). Bacterial biofilms are believed to have evolved in nature to give organisms a competitive advantage in high shear conditions, to protect microbes from environmental hazards (toxic substances or predatory cells), and to adapt to various nutritional conditions. Similarly, bacteria have exploited the biofilm model of existence in various infectious diseases and biomaterial-associated infections.

Original languageEnglish (US)
Title of host publicationBiofilms, Infection, and Antimicrobial Therapy
PublisherCRC Press
Pages289-303
Number of pages15
ISBN (Electronic)9781420028232
ISBN (Print)9780824726430
StatePublished - Jan 1 2005

Fingerprint

Biofilms
Biocompatible Materials
Staphylococcus
Bacteria
Infection
Phenotype
Hazardous Substances
Transcription
Growth
Extracellular Matrix
Communicable Diseases
Hazards
Genes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Chemistry(all)

Cite this

Handke, L. D., & Rupp, M. E. (2005). In Vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci. In Biofilms, Infection, and Antimicrobial Therapy (pp. 289-303). CRC Press.

In Vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci. / Handke, Luke D.; Rupp, Mark Edmund.

Biofilms, Infection, and Antimicrobial Therapy. CRC Press, 2005. p. 289-303.

Research output: Chapter in Book/Report/Conference proceedingChapter

Handke, LD & Rupp, ME 2005, In Vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci. in Biofilms, Infection, and Antimicrobial Therapy. CRC Press, pp. 289-303.
Handke LD, Rupp ME. In Vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci. In Biofilms, Infection, and Antimicrobial Therapy. CRC Press. 2005. p. 289-303
Handke, Luke D. ; Rupp, Mark Edmund. / In Vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci. Biofilms, Infection, and Antimicrobial Therapy. CRC Press, 2005. pp. 289-303
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