In vivo glucose absorption by neomucosa

Jon S Thompson, S. P. Moessner, T. Hollingsed

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Growing neomucosa has been investigated as a means of permanently increasing intestinal absorption in the short-bowel syndrome. The purpose of this study was to quantitate in vivo glucose absorption by neomucosa and correlate this with neomucosal growth. Thirteen New Zealand White rabbits (2.3 to 3.8 kg) had 2 by 5 cm ileal defects patched with colon serosa, and there was 12 control animals. Glucose absorption was determined by measuring the appearance of radioactivity in the portal vein and vena cava after topical application of [14C]-glucose. At 2 weeks the patched defect is partially covered by a thin layer of columnar epithelial cells. Mature villi are present at 8 weeks. The maximum rate of absorption by neomucosa was significantly greater 8 weeks after patching than at 2 or 4 weeks (0.067 ± 0.103 versus 0.020 ± 0.004 and 0.012 ± 0.003 μCi/min) but was significantly less than normal mucosa (0.264 ± 0.142 μCi/min, p < 0.05). Similarly, glucose absorption in the first 20 minutes by neomucosa was greater at 8 weeks than at 2 and 4 weeks (13.0% ± 6.2% versus 4.7% ± 0.5% and 6.5% ± 1.33%, p < 0.05). Colon serosa also absorbed significant glucose. Neomucosa absorbs glucose in vivo. The rate and amount of absorption correlate with neomucosal growth. Significant glucose absorption by colon serosa has implications for the transperitoneal delivery of nutrients.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalSurgery
Volume101
Issue number3
StatePublished - Jan 1 1987

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Glucose
Serous Membrane
Colon
Short Bowel Syndrome
Venae Cavae
Intestinal Absorption
Growth
Portal Vein
Radioactivity
Mucous Membrane
Epithelial Cells
Rabbits
Food

ASJC Scopus subject areas

  • Surgery

Cite this

Thompson, J. S., Moessner, S. P., & Hollingsed, T. (1987). In vivo glucose absorption by neomucosa. Surgery, 101(3), 297-303.

In vivo glucose absorption by neomucosa. / Thompson, Jon S; Moessner, S. P.; Hollingsed, T.

In: Surgery, Vol. 101, No. 3, 01.01.1987, p. 297-303.

Research output: Contribution to journalArticle

Thompson, JS, Moessner, SP & Hollingsed, T 1987, 'In vivo glucose absorption by neomucosa', Surgery, vol. 101, no. 3, pp. 297-303.
Thompson JS, Moessner SP, Hollingsed T. In vivo glucose absorption by neomucosa. Surgery. 1987 Jan 1;101(3):297-303.
Thompson, Jon S ; Moessner, S. P. ; Hollingsed, T. / In vivo glucose absorption by neomucosa. In: Surgery. 1987 ; Vol. 101, No. 3. pp. 297-303.
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