In vivo and in vitro methods for evaluating airways inflammation: Implications for respiratory toxicology

Stephen I. Rennard, David M. Daughton, Richard A. Robbins, Austin Bassett Thompson, Susanna G Von Essen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The lung is frequently the target of injury for toxic exposures. Often these exposures lead to significant disease. Assessment of toxic exposures to the lung, however, may be made using both in vitro and in vivo methods. Recent advances in respiratory cell biology have made possible in vitro analyses of the interactions between airway cells and potential toxins. In addition, the lung can be sampled in vivo using bronchoscopy and bronchoalveolar lavage. This opens up the possibility of assesing potential toxins prior to the development of clinically significant disease. Together, these advancing methodologies promise new potential for the assessment and evaluation of toxic exposures to the lung.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalToxicology
Volume60
Issue number1-2
DOIs
StatePublished - Jan 1 1990

Fingerprint

Poisons
Toxicology
Inflammation
Lung
Cytology
Bronchoscopy
Bronchoalveolar Lavage
Cell Biology
In Vitro Techniques
Wounds and Injuries

Keywords

  • Airway inflammation
  • Bronchoalveolar lavage
  • Chemotaxis
  • Epithelial cells
  • Injury, Repair

ASJC Scopus subject areas

  • Toxicology

Cite this

In vivo and in vitro methods for evaluating airways inflammation : Implications for respiratory toxicology. / Rennard, Stephen I.; Daughton, David M.; Robbins, Richard A.; Thompson, Austin Bassett; Von Essen, Susanna G.

In: Toxicology, Vol. 60, No. 1-2, 01.01.1990, p. 5-14.

Research output: Contribution to journalArticle

@article{f2bcdea733c543e0a755ac7f272fbf19,
title = "In vivo and in vitro methods for evaluating airways inflammation: Implications for respiratory toxicology",
abstract = "The lung is frequently the target of injury for toxic exposures. Often these exposures lead to significant disease. Assessment of toxic exposures to the lung, however, may be made using both in vitro and in vivo methods. Recent advances in respiratory cell biology have made possible in vitro analyses of the interactions between airway cells and potential toxins. In addition, the lung can be sampled in vivo using bronchoscopy and bronchoalveolar lavage. This opens up the possibility of assesing potential toxins prior to the development of clinically significant disease. Together, these advancing methodologies promise new potential for the assessment and evaluation of toxic exposures to the lung.",
keywords = "Airway inflammation, Bronchoalveolar lavage, Chemotaxis, Epithelial cells, Injury, Repair",
author = "Rennard, {Stephen I.} and Daughton, {David M.} and Robbins, {Richard A.} and Thompson, {Austin Bassett} and {Von Essen}, {Susanna G}",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0300-483X(90)90158-D",
language = "English (US)",
volume = "60",
pages = "5--14",
journal = "Toxicology",
issn = "0300-483X",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - In vivo and in vitro methods for evaluating airways inflammation

T2 - Implications for respiratory toxicology

AU - Rennard, Stephen I.

AU - Daughton, David M.

AU - Robbins, Richard A.

AU - Thompson, Austin Bassett

AU - Von Essen, Susanna G

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The lung is frequently the target of injury for toxic exposures. Often these exposures lead to significant disease. Assessment of toxic exposures to the lung, however, may be made using both in vitro and in vivo methods. Recent advances in respiratory cell biology have made possible in vitro analyses of the interactions between airway cells and potential toxins. In addition, the lung can be sampled in vivo using bronchoscopy and bronchoalveolar lavage. This opens up the possibility of assesing potential toxins prior to the development of clinically significant disease. Together, these advancing methodologies promise new potential for the assessment and evaluation of toxic exposures to the lung.

AB - The lung is frequently the target of injury for toxic exposures. Often these exposures lead to significant disease. Assessment of toxic exposures to the lung, however, may be made using both in vitro and in vivo methods. Recent advances in respiratory cell biology have made possible in vitro analyses of the interactions between airway cells and potential toxins. In addition, the lung can be sampled in vivo using bronchoscopy and bronchoalveolar lavage. This opens up the possibility of assesing potential toxins prior to the development of clinically significant disease. Together, these advancing methodologies promise new potential for the assessment and evaluation of toxic exposures to the lung.

KW - Airway inflammation

KW - Bronchoalveolar lavage

KW - Chemotaxis

KW - Epithelial cells

KW - Injury, Repair

UR - http://www.scopus.com/inward/record.url?scp=0025159292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025159292&partnerID=8YFLogxK

U2 - 10.1016/0300-483X(90)90158-D

DO - 10.1016/0300-483X(90)90158-D

M3 - Article

C2 - 2180133

AN - SCOPUS:0025159292

VL - 60

SP - 5

EP - 14

JO - Toxicology

JF - Toxicology

SN - 0300-483X

IS - 1-2

ER -