In vivo activity of aryl ozonides against Schistosoma species

Jennifer Keiser, Katrin Ingram, Mireille Vargas, Jacques Chollet, Xiaofang Wang, Yuxiang Dong, Jonathan L. Vennerstrom

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P<0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.

Original languageEnglish (US)
Pages (from-to)1090-1092
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number2
DOIs
StatePublished - Feb 1 2012

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Schistosoma
Schistosoma mansoni
Peroxides
1,2,4-trioxane
Lead

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

In vivo activity of aryl ozonides against Schistosoma species. / Keiser, Jennifer; Ingram, Katrin; Vargas, Mireille; Chollet, Jacques; Wang, Xiaofang; Dong, Yuxiang; Vennerstrom, Jonathan L.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 2, 01.02.2012, p. 1090-1092.

Research output: Contribution to journalArticle

Keiser, Jennifer ; Ingram, Katrin ; Vargas, Mireille ; Chollet, Jacques ; Wang, Xiaofang ; Dong, Yuxiang ; Vennerstrom, Jonathan L. / In vivo activity of aryl ozonides against Schistosoma species. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 2. pp. 1090-1092.
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