In vitro inhibition of rat intestinal histamine-metabolizing enzymes

S. L. Taylor, E. R. Lieber

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

When used at 10 mm concentrations in assays in vitro, seven of 37 chemicals strongly inhibited (> 75% inhibition) rat jejunal mucosa histamine-N-methyltransferase (HMT), while eight of 37 chemicals strongly inhibited rat jejunal mucosa diamine oxidase (DAO). The HMT inhibitors included tyramine, β-phenylethylamine, tryptamine, octopamine, agmatine, aminoguanidine and nicotine. The most potent DAO inhibitors were aminoguanidine, anserine, carnosine, histamine, agmatine, thiamine, cadaverine and tyramine. Since many of these inhibitors occur together with histamine in spoiled tuna, the inhibition of the two major intestinal histamine-catabolizing enzymes, HMT and DAO, may play a vital role in the chemical potentiation of histamine toxicity.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalFood and Cosmetics Toxicology
Volume17
Issue number3
DOIs
StatePublished - 1979

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histamine N-methyltransferase
Histamine N-Methyltransferase
histamine
Amine Oxidase (Copper-Containing)
Histamine
Rats
Agmatine
agmatine
Tyramine
tyramine
rats
Enzymes
enzymes
mucosa
Mucous Membrane
Anserine
anserine
Carnosine
Octopamine
Cadaverine

ASJC Scopus subject areas

  • Toxicology

Cite this

In vitro inhibition of rat intestinal histamine-metabolizing enzymes. / Taylor, S. L.; Lieber, E. R.

In: Food and Cosmetics Toxicology, Vol. 17, No. 3, 1979, p. 237-240.

Research output: Contribution to journalArticle

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