In vitro genotoxic effects of areca nut extract and arecoline

Bhavana J Dave, Amit H. Trivedi, Siddharth G. Adhvaryu

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The genotoxic potential of the aqueous extract of areca nut as well as arecoline, the major alkaloid of the areca nut, was tested with the help of cytogenetic markers such as sister-chromatid exchanges and chromosome aberrations, utilizing Chinese hamster ovary (CHO) cells. The continuous-treatment and pulse-treatment schedules yielded dose-dependent elevations in the frequencies of sister-chromatid exchange and chromosomal aberration in CHO cells, indicating a genotoxic effect of both the extract and arecoline. The results also imply that, besides arecoline, there may be some other water-extractable substances in the areca nut that make the extract more genotoxic. The chromosome damage was found to be more severe on treating the cells with low concentrations and for longer duration, which mimic the effects of chronic areca nut consumption.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalJournal of Cancer Research and Clinical Oncology
Volume118
Issue number4
DOIs
StatePublished - Apr 1 1992

Fingerprint

Arecoline
Areca
Nuts
Sister Chromatid Exchange
Cricetulus
Chromosome Aberrations
Ovary
Alkaloids
Cytogenetics
Appointments and Schedules
Chromosomes
In Vitro Techniques
Water

Keywords

  • Areca nut
  • Arecoline
  • Chromosome aberrations
  • Genotoxicity
  • Sister chromatid exchange

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

In vitro genotoxic effects of areca nut extract and arecoline. / Dave, Bhavana J; Trivedi, Amit H.; Adhvaryu, Siddharth G.

In: Journal of Cancer Research and Clinical Oncology, Vol. 118, No. 4, 01.04.1992, p. 283-288.

Research output: Contribution to journalArticle

Dave, Bhavana J ; Trivedi, Amit H. ; Adhvaryu, Siddharth G. / In vitro genotoxic effects of areca nut extract and arecoline. In: Journal of Cancer Research and Clinical Oncology. 1992 ; Vol. 118, No. 4. pp. 283-288.
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