In vitro evaluation of embolization effects of thermosensitive N-isopropylacrylamide-based copolymer solutions

Feng Tian, Bingqi Zhang, Xiaoli Zhao, Weihang Ji, Xiaowei Li, Guoxiang Cheng, Kangde Yao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Thermosensitive N-isopropylacrylamide (NIPAAm)-co-(N-propylacrylamide (NPAAm)-co-vinyl pyrrolidone (VP) terpolymers (PNINAVP) were synthesized by conventional free-radical polymerization. The thermoresponsive behaviour of their solutions was investigated by turbidimetry and dynamic contact angle (DCA) measurements. The sol-gel transition of the copolymer solutions occurred reversibly within 30 s, in response to the change of temperature. In vitro embolic model experiments indicated that a 5 wt% solution of 16:16:1 PNINAVP had a satisfactory embolization effect.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalPolymer International
Volume55
Issue number4
DOIs
StatePublished - Apr 1 2006

Fingerprint

Copolymers
Pyrrolidinones
Terpolymers
Angle measurement
Free radical polymerization
Contact angle
Sol-gels
N-isopropylacrylamide
Experiments
Temperature

Keywords

  • Liquid embolic agent
  • N-isopropylacrylamide
  • N-propylacrylamide
  • Thermosensitive
  • Vinyl pyrrolidone

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

In vitro evaluation of embolization effects of thermosensitive N-isopropylacrylamide-based copolymer solutions. / Tian, Feng; Zhang, Bingqi; Zhao, Xiaoli; Ji, Weihang; Li, Xiaowei; Cheng, Guoxiang; Yao, Kangde.

In: Polymer International, Vol. 55, No. 4, 01.04.2006, p. 405-408.

Research output: Contribution to journalArticle

Tian, Feng ; Zhang, Bingqi ; Zhao, Xiaoli ; Ji, Weihang ; Li, Xiaowei ; Cheng, Guoxiang ; Yao, Kangde. / In vitro evaluation of embolization effects of thermosensitive N-isopropylacrylamide-based copolymer solutions. In: Polymer International. 2006 ; Vol. 55, No. 4. pp. 405-408.
@article{986bf1ec47a64e1a88621102ab5282cc,
title = "In vitro evaluation of embolization effects of thermosensitive N-isopropylacrylamide-based copolymer solutions",
abstract = "Thermosensitive N-isopropylacrylamide (NIPAAm)-co-(N-propylacrylamide (NPAAm)-co-vinyl pyrrolidone (VP) terpolymers (PNINAVP) were synthesized by conventional free-radical polymerization. The thermoresponsive behaviour of their solutions was investigated by turbidimetry and dynamic contact angle (DCA) measurements. The sol-gel transition of the copolymer solutions occurred reversibly within 30 s, in response to the change of temperature. In vitro embolic model experiments indicated that a 5 wt{\%} solution of 16:16:1 PNINAVP had a satisfactory embolization effect.",
keywords = "Liquid embolic agent, N-isopropylacrylamide, N-propylacrylamide, Thermosensitive, Vinyl pyrrolidone",
author = "Feng Tian and Bingqi Zhang and Xiaoli Zhao and Weihang Ji and Xiaowei Li and Guoxiang Cheng and Kangde Yao",
year = "2006",
month = "4",
day = "1",
doi = "10.1002/pi.1975",
language = "English (US)",
volume = "55",
pages = "405--408",
journal = "Polymer International",
issn = "0959-8103",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

TY - JOUR

T1 - In vitro evaluation of embolization effects of thermosensitive N-isopropylacrylamide-based copolymer solutions

AU - Tian, Feng

AU - Zhang, Bingqi

AU - Zhao, Xiaoli

AU - Ji, Weihang

AU - Li, Xiaowei

AU - Cheng, Guoxiang

AU - Yao, Kangde

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Thermosensitive N-isopropylacrylamide (NIPAAm)-co-(N-propylacrylamide (NPAAm)-co-vinyl pyrrolidone (VP) terpolymers (PNINAVP) were synthesized by conventional free-radical polymerization. The thermoresponsive behaviour of their solutions was investigated by turbidimetry and dynamic contact angle (DCA) measurements. The sol-gel transition of the copolymer solutions occurred reversibly within 30 s, in response to the change of temperature. In vitro embolic model experiments indicated that a 5 wt% solution of 16:16:1 PNINAVP had a satisfactory embolization effect.

AB - Thermosensitive N-isopropylacrylamide (NIPAAm)-co-(N-propylacrylamide (NPAAm)-co-vinyl pyrrolidone (VP) terpolymers (PNINAVP) were synthesized by conventional free-radical polymerization. The thermoresponsive behaviour of their solutions was investigated by turbidimetry and dynamic contact angle (DCA) measurements. The sol-gel transition of the copolymer solutions occurred reversibly within 30 s, in response to the change of temperature. In vitro embolic model experiments indicated that a 5 wt% solution of 16:16:1 PNINAVP had a satisfactory embolization effect.

KW - Liquid embolic agent

KW - N-isopropylacrylamide

KW - N-propylacrylamide

KW - Thermosensitive

KW - Vinyl pyrrolidone

UR - http://www.scopus.com/inward/record.url?scp=33645455935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645455935&partnerID=8YFLogxK

U2 - 10.1002/pi.1975

DO - 10.1002/pi.1975

M3 - Article

AN - SCOPUS:33645455935

VL - 55

SP - 405

EP - 408

JO - Polymer International

JF - Polymer International

SN - 0959-8103

IS - 4

ER -