Improving the lives of patients with medically refractory epilepsy by electrical stimulation of the nervous system

Jerome V. Murphy, Arun Angelo Patil

Research output: Contribution to journalReview article

5 Scopus citations


Vagal nerve stimulation proved effective in animal models of epilepsy, and in open and double-blinded trials, in over 450 patients. Seizure reduction improved for at least 2 years. Almost 60% of treated patients achieve at least a 50% reduction in seizure frequency. Other advantages include termination of a seizure and improved alertness. Benefits were demonstrated in children, partial and generalized epilepsies, and in specific neurologic syndromes.

Original languageEnglish (US)
Pages (from-to)175-189
Number of pages15
JournalExpert Review of Medical Devices
Issue number2
StatePublished - Mar 2005



  • Deep brain stimulation
  • Refractory epilepsy
  • Vagal nerve stimulation

ASJC Scopus subject areas

  • Surgery
  • Biomedical Engineering

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