Improving catalyst scope

Use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization

James M Takacs, Jianxin Han

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

(Chemical Equation Presented) Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization-trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.

Original languageEnglish (US)
Pages (from-to)3099-3102
Number of pages4
JournalOrganic Letters
Volume6
Issue number18
DOIs
StatePublished - Sep 2 2004

Fingerprint

Aniline Compounds
Cyclization
Palladium
aniline
palladium
trapping
Ligands
catalysts
Catalysts
Substrates
reagents
Screening
screening
ligands
optimization
electronics

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Improving catalyst scope : Use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization. / Takacs, James M; Han, Jianxin.

In: Organic Letters, Vol. 6, No. 18, 02.09.2004, p. 3099-3102.

Research output: Contribution to journalArticle

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