Improved estimation of dynamic connectivity from resting-state fMRI data

Biao Cai, Julia M. Stephen, Tony W. Wilson, Vince D. Calhoun, Yu Ping Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional magnetic resonance imaging (fMRI) has been widely used for neuronal connectivity analysis. As a datadriven technique, independent component analysis (ICA) has become a valuable tool for fMRI studies. Recently, due to the dynamic nature of the human brain, time-varying connectivity analysis is regarded as an important measure to reveal essential information within the network. The sliding window approach has been commonly used to extract dynamic information from fMRI time series. However, it has some limitations due to the assumption that connectivity at a given time can be estimated from all the samples of the input time series data spanned by the selected window. To address this issue, we apply a time-varying graphical lasso model (TVGL) proposed by Hallac et al., which can infer the network even when the observation interval is at only one time point. On the other hand, recent results have shown that the individual's connectivity profiles can be used as "fingerprint" to identify subjects from a large group. We hypothesize that the subject-specific FC profiles may have the critical effect on analyzing FC dynamics at a group level. In this work, we apply a group ICA (GICA) based data-driven framework to assess dynamic functional network connectivity (dFNC), based on the combination of GICA and TVGL. Also, we use the regression model to remove the subject-specific individuality in detecting functional dynamics. The results prove our hypothesis and suggest that removing the individual effect may benefit us to assess the connectivity dynamics within the human brain.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2019
Subtitle of host publicationImage Processing
EditorsElsa D. Angelini, Elsa D. Angelini, Elsa D. Angelini, Bennett A. Landman
PublisherSPIE
ISBN (Electronic)9781510625457
DOIs
StatePublished - Jan 1 2019
EventMedical Imaging 2019: Image Processing - San Diego, United States
Duration: Feb 19 2019Feb 21 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10949
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2019: Image Processing
CountryUnited States
CitySan Diego
Period2/19/192/21/19

Fingerprint

magnetic resonance
Magnetic Resonance Imaging
Independent component analysis
Time series
Brain
brain
Information Services
Dermatoglyphics
profiles
Individuality
sliding
regression analysis
Observation
intervals
alachlor

Keywords

  • Brain Development
  • Dynamic Functional Connectivity
  • Resting-state fMRI
  • Subject-specific Individuality

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Cai, B., Stephen, J. M., Wilson, T. W., Calhoun, V. D., & Wang, Y. P. (2019). Improved estimation of dynamic connectivity from resting-state fMRI data. In E. D. Angelini, E. D. Angelini, E. D. Angelini, & B. A. Landman (Eds.), Medical Imaging 2019: Image Processing [109490P] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10949). SPIE. https://doi.org/10.1117/12.2512976

Improved estimation of dynamic connectivity from resting-state fMRI data. / Cai, Biao; Stephen, Julia M.; Wilson, Tony W.; Calhoun, Vince D.; Wang, Yu Ping.

Medical Imaging 2019: Image Processing. ed. / Elsa D. Angelini; Elsa D. Angelini; Elsa D. Angelini; Bennett A. Landman. SPIE, 2019. 109490P (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10949).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cai, B, Stephen, JM, Wilson, TW, Calhoun, VD & Wang, YP 2019, Improved estimation of dynamic connectivity from resting-state fMRI data. in ED Angelini, ED Angelini, ED Angelini & BA Landman (eds), Medical Imaging 2019: Image Processing., 109490P, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10949, SPIE, Medical Imaging 2019: Image Processing, San Diego, United States, 2/19/19. https://doi.org/10.1117/12.2512976
Cai B, Stephen JM, Wilson TW, Calhoun VD, Wang YP. Improved estimation of dynamic connectivity from resting-state fMRI data. In Angelini ED, Angelini ED, Angelini ED, Landman BA, editors, Medical Imaging 2019: Image Processing. SPIE. 2019. 109490P. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2512976
Cai, Biao ; Stephen, Julia M. ; Wilson, Tony W. ; Calhoun, Vince D. ; Wang, Yu Ping. / Improved estimation of dynamic connectivity from resting-state fMRI data. Medical Imaging 2019: Image Processing. editor / Elsa D. Angelini ; Elsa D. Angelini ; Elsa D. Angelini ; Bennett A. Landman. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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