Improved arene fluorination methodology for I(III) salts

Bijia Wang, Linlin Qin, Kiel D. Neumann, Shriharsha Uppaluri, Ronald Cerny, Stephen G. DiMagno

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

(Equation Presented). The use of low polarity aromatic solvents (benzene or toluene) and/or the removal of inorganic salts results in dramatically improved yields of fluorinated arenes from diaryliodonium salts. This methodology is shown to "scale down" to the conditions used typically for radiotracer synthesis.

Original languageEnglish (US)
Pages (from-to)3352-3355
Number of pages4
JournalOrganic Letters
Volume12
Issue number15
DOIs
StatePublished - Aug 6 2010

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Fluorination
fluorination
Halogenation
Salts
methodology
salts
Toluene
Benzene
toluene
polarity
benzene
synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Wang, B., Qin, L., Neumann, K. D., Uppaluri, S., Cerny, R., & DiMagno, S. G. (2010). Improved arene fluorination methodology for I(III) salts. Organic Letters, 12(15), 3352-3355. https://doi.org/10.1021/ol101154h

Improved arene fluorination methodology for I(III) salts. / Wang, Bijia; Qin, Linlin; Neumann, Kiel D.; Uppaluri, Shriharsha; Cerny, Ronald; DiMagno, Stephen G.

In: Organic Letters, Vol. 12, No. 15, 06.08.2010, p. 3352-3355.

Research output: Contribution to journalArticle

Wang, B, Qin, L, Neumann, KD, Uppaluri, S, Cerny, R & DiMagno, SG 2010, 'Improved arene fluorination methodology for I(III) salts', Organic Letters, vol. 12, no. 15, pp. 3352-3355. https://doi.org/10.1021/ol101154h
Wang B, Qin L, Neumann KD, Uppaluri S, Cerny R, DiMagno SG. Improved arene fluorination methodology for I(III) salts. Organic Letters. 2010 Aug 6;12(15):3352-3355. https://doi.org/10.1021/ol101154h
Wang, Bijia ; Qin, Linlin ; Neumann, Kiel D. ; Uppaluri, Shriharsha ; Cerny, Ronald ; DiMagno, Stephen G. / Improved arene fluorination methodology for I(III) salts. In: Organic Letters. 2010 ; Vol. 12, No. 15. pp. 3352-3355.
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