Improved arene fluorination methodology for I(III) salts

Bijia Wang, Linlin Qin, Kiel D. Neumann, Shriharsha Uppaluri, Ronald L. Cerny, Stephen G. DiMagno

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Abstract

(Equation Presented). The use of low polarity aromatic solvents (benzene or toluene) and/or the removal of inorganic salts results in dramatically improved yields of fluorinated arenes from diaryliodonium salts. This methodology is shown to "scale down" to the conditions used typically for radiotracer synthesis.

Original languageEnglish (US)
Pages (from-to)3352-3355
Number of pages4
JournalOrganic Letters
Volume12
Issue number15
DOIs
StatePublished - Aug 6 2010

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Wang, B., Qin, L., Neumann, K. D., Uppaluri, S., Cerny, R. L., & DiMagno, S. G. (2010). Improved arene fluorination methodology for I(III) salts. Organic Letters, 12(15), 3352-3355. https://doi.org/10.1021/ol101154h