Importance of interleukin-3 on histamine release from human basophils

H. Sugiyama, R. Eda, R. J. Hopp, A. K. Bewtra, R. G. Townley

Research output: Contribution to journalArticle

19 Scopus citations


We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P < .0001).

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalAnnals of Allergy
Issue number4
StatePublished - Jan 1 1993


ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Sugiyama, H., Eda, R., Hopp, R. J., Bewtra, A. K., & Townley, R. G. (1993). Importance of interleukin-3 on histamine release from human basophils. Annals of Allergy, 71(4), 391-395.